Molecular chaperones in antigen presentation

As is the case with most proteins of the secretory pathway, the biogenesis of MHC class I and class II molecules occurs in association with molecular chaperones. Considerable progress has been made in identifying the chaperones involved and recent studies on two of these, calnexin and invariant chai...

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Published in:Current opinion in immunology 1995-02, Vol.7 (1), p.77-84
Main Authors: Williams, David B, Watts, Tania H
Format: Article
Language:English
Subjects:
Animals
Antigen Presentation - immunology
Humans
Molecular Chaperones - immunology
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description As is the case with most proteins of the secretory pathway, the biogenesis of MHC class I and class II molecules occurs in association with molecular chaperones. Considerable progress has been made in identifying the chaperones involved and recent studies on two of these, calnexin and invariant chain, have shown that they influence multiple processes including protein stability, folding, assembly and intercellular retention.
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subjects Animals
Antigen Presentation - immunology
Humans
Molecular Chaperones - immunology
title Molecular chaperones in antigen presentation
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