The role of mast cells and diet in the onset and maintenance of multiple sclerosis: A hypothesis

Mast cells may invade the brain as a consequence of a childhood infection or predisposition, and it is proposed that multiple sclerosis arises due to the effect of various mediators (histamine and protease) released from the perivascular mast cells after stimulation by some diet factor.

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Bibliographic Details
Published in:Medical hypotheses 1995, Vol.44 (1), p.66-69
Main Authors: Krüger, P.G., Nyland, H.I.
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Climate
Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
Diet
Endopeptidases - metabolism
Histamine - metabolism
Humans
Mast Cells - physiology
Medical sciences
Multiple Sclerosis - epidemiology
Multiple Sclerosis - etiology
Multiple Sclerosis - physiopathology
Neurology
Philosophy
Risk Factors
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Description
Summary:Mast cells may invade the brain as a consequence of a childhood infection or predisposition, and it is proposed that multiple sclerosis arises due to the effect of various mediators (histamine and protease) released from the perivascular mast cells after stimulation by some diet factor.
ISSN:0306-9877
1532-2777
DOI:10.1016/0306-9877(95)90305-4