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The drosophila schnurri gene acts in the Dpp/TGFβ signaling pathway and encodes a transcription factor homologous to the human MBP family
Decapentaplegic (dpp), a TGFβ-related ligand, plays a key role in Drosophila development. Although dpp receptors have been isolated, the downstream components of the signaling pathway remain to be identified. We have cloned the schnurri(shnn) gene and show that it encodes a putative zinc finger tran...
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| Published in: | Cell 1995-06, Vol.81 (5), p.781-790 |
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| Main Authors: | , , , , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c434t-76919e68503f658ceb50777ad7fecd6a59891b4a016a36843879cffeb6981bf33 |
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| cites | cdi_FETCH-LOGICAL-c434t-76919e68503f658ceb50777ad7fecd6a59891b4a016a36843879cffeb6981bf33 |
| container_end_page | 790 |
| container_issue | 5 |
| container_start_page | 781 |
| container_title | Cell |
| container_volume | 81 |
| creator | Arora, Kavita Dai, Heng Kazuko, Sandra G Jamal, Joumana O'Connor, Michael B Letsou, Anthea Warrior, Rahul |
| description | Decapentaplegic (dpp), a TGFβ-related ligand, plays a key role in Drosophila development. Although dpp receptors have been isolated, the downstream components of the signaling pathway remain to be identified. We have cloned the
schnurri(shnn) gene and show that it encodes a putative zinc finger transcription factor homologous to the human major histocompatibility complex-binding proteins 1 and 2. Mutations in
shn affect multiple events that require dpp signaling as well as the transcription of dpp-responsive genes. Genetic interactions and the strikingly similar phenotypes of mutations in
shn and the dpp receptors encoded by
thick veins and
punt suggest that
shn plays a downstream role in dpp signaling. |
| doi_str_mv | 10.1016/0092-8674(95)90539-1 |
| format | article |
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schnurri(shnn) gene and show that it encodes a putative zinc finger transcription factor homologous to the human major histocompatibility complex-binding proteins 1 and 2. Mutations in
shn affect multiple events that require dpp signaling as well as the transcription of dpp-responsive genes. Genetic interactions and the strikingly similar phenotypes of mutations in
shn and the dpp receptors encoded by
thick veins and
punt suggest that
shn plays a downstream role in dpp signaling.</description><identifier>ISSN: 0092-8674</identifier><identifier>EISSN: 1097-4172</identifier><identifier>DOI: 10.1016/0092-8674(95)90539-1</identifier><identifier>PMID: 7774017</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Amino Acid Sequence ; Animals ; Base Sequence ; Bone Morphogenetic Proteins ; Cloning, Molecular ; DNA-Binding Proteins - genetics ; DNA-Binding Proteins - metabolism ; Drosophila ; Drosophila - embryology ; Drosophila - genetics ; Drosophila Proteins ; Ectoderm - physiology ; Genes, Insect - genetics ; Histocytochemistry ; Insect Hormones - metabolism ; Mesoderm - physiology ; Molecular Sequence Data ; Mutation ; Proteins - genetics ; RNA, Messenger - genetics ; RNA, Messenger - isolation & purification ; Sequence Analysis, DNA ; Sequence Homology, Amino Acid ; Signal Transduction - genetics ; Tissue Distribution ; Tissue Transplantation ; Transcription Factors - genetics ; Transcription Factors - metabolism ; Transforming Growth Factor beta - metabolism ; Zinc Fingers - genetics</subject><ispartof>Cell, 1995-06, Vol.81 (5), p.781-790</ispartof><rights>1995</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c434t-76919e68503f658ceb50777ad7fecd6a59891b4a016a36843879cffeb6981bf33</citedby><cites>FETCH-LOGICAL-c434t-76919e68503f658ceb50777ad7fecd6a59891b4a016a36843879cffeb6981bf33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0092867495905391$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,3549,27924,27925,45780</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7774017$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Arora, Kavita</creatorcontrib><creatorcontrib>Dai, Heng</creatorcontrib><creatorcontrib>Kazuko, Sandra G</creatorcontrib><creatorcontrib>Jamal, Joumana</creatorcontrib><creatorcontrib>O'Connor, Michael B</creatorcontrib><creatorcontrib>Letsou, Anthea</creatorcontrib><creatorcontrib>Warrior, Rahul</creatorcontrib><title>The drosophila schnurri gene acts in the Dpp/TGFβ signaling pathway and encodes a transcription factor homologous to the human MBP family</title><title>Cell</title><addtitle>Cell</addtitle><description>Decapentaplegic (dpp), a TGFβ-related ligand, plays a key role in Drosophila development. Although dpp receptors have been isolated, the downstream components of the signaling pathway remain to be identified. We have cloned the
schnurri(shnn) gene and show that it encodes a putative zinc finger transcription factor homologous to the human major histocompatibility complex-binding proteins 1 and 2. Mutations in
shn affect multiple events that require dpp signaling as well as the transcription of dpp-responsive genes. Genetic interactions and the strikingly similar phenotypes of mutations in
shn and the dpp receptors encoded by
thick veins and
punt suggest that
shn plays a downstream role in dpp signaling.</description><subject>Amino Acid Sequence</subject><subject>Animals</subject><subject>Base Sequence</subject><subject>Bone Morphogenetic Proteins</subject><subject>Cloning, Molecular</subject><subject>DNA-Binding Proteins - genetics</subject><subject>DNA-Binding Proteins - metabolism</subject><subject>Drosophila</subject><subject>Drosophila - embryology</subject><subject>Drosophila - genetics</subject><subject>Drosophila Proteins</subject><subject>Ectoderm - physiology</subject><subject>Genes, Insect - genetics</subject><subject>Histocytochemistry</subject><subject>Insect Hormones - metabolism</subject><subject>Mesoderm - physiology</subject><subject>Molecular Sequence Data</subject><subject>Mutation</subject><subject>Proteins - genetics</subject><subject>RNA, Messenger - genetics</subject><subject>RNA, Messenger - isolation & purification</subject><subject>Sequence Analysis, DNA</subject><subject>Sequence Homology, Amino Acid</subject><subject>Signal Transduction - genetics</subject><subject>Tissue Distribution</subject><subject>Tissue Transplantation</subject><subject>Transcription Factors - genetics</subject><subject>Transcription Factors - metabolism</subject><subject>Transforming Growth Factor beta - metabolism</subject><subject>Zinc Fingers - genetics</subject><issn>0092-8674</issn><issn>1097-4172</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><recordid>eNqFkc1u1DAURi1EVYbCG4DkFYJFWnvi3w0SFFoqFcFiWFuOczMxSuxgJ6B5BR6HB-GZ8HRGXdKVF_fcz_b5EHpByTklVFwQoteVEpK91vyNJrzWFX2EVpRoWTEq14_R6h55gp7m_J0Qojjnp-hUSskIlSv0e9MDblPMcer9YHF2fVhS8ngLAbB1c8Y-4LlAH6bpYnN99fcPzn4b7ODDFk927n_ZHbahxRBcbCFji-dkQ3bJT7OPAXclJCbcxzEOcRuXjOd4F9gvow348_uvBRn9sHuGTjo7ZHh-PM_Qt6uPm8tP1e2X65vLd7eVYzWbKyk01SAUJ3UnuHLQcFK-Y1vZgWuF5Vpp2jBbFNlaKFYrqV3XQSO0ok1X12fo1SF3SvHHAnk2o88OhsEGKM8zUtaUKaYeBKlQxS9fF5AdQFdE5gSdmZIfbdoZSsy-K7MvwuyLMJqbu64MLWsvj_lLM0J7v3Qsp8zfHuZQbPz0kEx2vmiG1idws2mj__8F_wACzaUr</recordid><startdate>19950602</startdate><enddate>19950602</enddate><creator>Arora, Kavita</creator><creator>Dai, Heng</creator><creator>Kazuko, Sandra G</creator><creator>Jamal, Joumana</creator><creator>O'Connor, Michael B</creator><creator>Letsou, Anthea</creator><creator>Warrior, Rahul</creator><general>Elsevier Inc</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SS</scope><scope>7TM</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>19950602</creationdate><title>The drosophila schnurri gene acts in the Dpp/TGFβ signaling pathway and encodes a transcription factor homologous to the human MBP family</title><author>Arora, Kavita ; Dai, Heng ; Kazuko, Sandra G ; Jamal, Joumana ; O'Connor, Michael B ; Letsou, Anthea ; Warrior, Rahul</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c434t-76919e68503f658ceb50777ad7fecd6a59891b4a016a36843879cffeb6981bf33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Amino Acid Sequence</topic><topic>Animals</topic><topic>Base Sequence</topic><topic>Bone Morphogenetic Proteins</topic><topic>Cloning, Molecular</topic><topic>DNA-Binding Proteins - genetics</topic><topic>DNA-Binding Proteins - metabolism</topic><topic>Drosophila</topic><topic>Drosophila - embryology</topic><topic>Drosophila - genetics</topic><topic>Drosophila Proteins</topic><topic>Ectoderm - physiology</topic><topic>Genes, Insect - genetics</topic><topic>Histocytochemistry</topic><topic>Insect Hormones - metabolism</topic><topic>Mesoderm - physiology</topic><topic>Molecular Sequence Data</topic><topic>Mutation</topic><topic>Proteins - genetics</topic><topic>RNA, Messenger - genetics</topic><topic>RNA, Messenger - isolation & purification</topic><topic>Sequence Analysis, DNA</topic><topic>Sequence Homology, Amino Acid</topic><topic>Signal Transduction - genetics</topic><topic>Tissue Distribution</topic><topic>Tissue Transplantation</topic><topic>Transcription Factors - genetics</topic><topic>Transcription Factors - metabolism</topic><topic>Transforming Growth Factor beta - metabolism</topic><topic>Zinc Fingers - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Arora, Kavita</creatorcontrib><creatorcontrib>Dai, Heng</creatorcontrib><creatorcontrib>Kazuko, Sandra G</creatorcontrib><creatorcontrib>Jamal, Joumana</creatorcontrib><creatorcontrib>O'Connor, Michael B</creatorcontrib><creatorcontrib>Letsou, Anthea</creatorcontrib><creatorcontrib>Warrior, Rahul</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Cell</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Arora, Kavita</au><au>Dai, Heng</au><au>Kazuko, Sandra G</au><au>Jamal, Joumana</au><au>O'Connor, Michael B</au><au>Letsou, Anthea</au><au>Warrior, Rahul</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The drosophila schnurri gene acts in the Dpp/TGFβ signaling pathway and encodes a transcription factor homologous to the human MBP family</atitle><jtitle>Cell</jtitle><addtitle>Cell</addtitle><date>1995-06-02</date><risdate>1995</risdate><volume>81</volume><issue>5</issue><spage>781</spage><epage>790</epage><pages>781-790</pages><issn>0092-8674</issn><eissn>1097-4172</eissn><abstract>Decapentaplegic (dpp), a TGFβ-related ligand, plays a key role in Drosophila development. Although dpp receptors have been isolated, the downstream components of the signaling pathway remain to be identified. We have cloned the
schnurri(shnn) gene and show that it encodes a putative zinc finger transcription factor homologous to the human major histocompatibility complex-binding proteins 1 and 2. Mutations in
shn affect multiple events that require dpp signaling as well as the transcription of dpp-responsive genes. Genetic interactions and the strikingly similar phenotypes of mutations in
shn and the dpp receptors encoded by
thick veins and
punt suggest that
shn plays a downstream role in dpp signaling.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>7774017</pmid><doi>10.1016/0092-8674(95)90539-1</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Cell, 1995-06, Vol.81 (5), p.781-790 |
| issn | 0092-8674 1097-4172 |
| language | eng |
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| source | ScienceDirect Journals |
| subjects | Amino Acid Sequence Animals Base Sequence Bone Morphogenetic Proteins Cloning, Molecular DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Drosophila Drosophila - embryology Drosophila - genetics Drosophila Proteins Ectoderm - physiology Genes, Insect - genetics Histocytochemistry Insect Hormones - metabolism Mesoderm - physiology Molecular Sequence Data Mutation Proteins - genetics RNA, Messenger - genetics RNA, Messenger - isolation & purification Sequence Analysis, DNA Sequence Homology, Amino Acid Signal Transduction - genetics Tissue Distribution Tissue Transplantation Transcription Factors - genetics Transcription Factors - metabolism Transforming Growth Factor beta - metabolism Zinc Fingers - genetics |
| title | The drosophila schnurri gene acts in the Dpp/TGFβ signaling pathway and encodes a transcription factor homologous to the human MBP family |
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