Risk of recurrent stroke in patients with sickle cell disease treated with erythrocyte transfusions

Objective: To determine the effect of a transfusion program on risk of stroke recurrence in children with sickle cell disease. Design: The clinical course and experience with transfusion therapy at eight centers were reviewed for subjects whose initial stroke occurred after January 1988. Results: Si...

Full description

Saved in:
Bibliographic Details
Published in:The Journal of pediatrics 1995-06, Vol.126 (6), p.896-899
Main Authors: Pegelow, Charles H., Adams, Robert J., McKie, Virgil, Abboud, Miguel, Berman, Brian, Miller, Scott T., Olivieri, Nancy, Vichinsky, Elliott, Wang, Winfred, Brambilla, Donald
Format: Article
Language:English
Subjects:
Adolescent
Adult
Anemia, Sickle Cell - therapy
Anemias. Hemoglobinopathies
Biological and medical sciences
Cerebral Infarction - etiology
Cerebral Infarction - prevention & control
Cerebrovascular Disorders - etiology
Cerebrovascular Disorders - prevention & control
Child
Child, Preschool
Diseases of red blood cells
Erythrocyte Transfusion
Female
Hematologic and hematopoietic diseases
Hemoglobin, Sickle - analysis
Humans
Infant
Male
Medical sciences
Recurrence
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Objective: To determine the effect of a transfusion program on risk of stroke recurrence in children with sickle cell disease. Design: The clinical course and experience with transfusion therapy at eight centers were reviewed for subjects whose initial stroke occurred after January 1988. Results: Sixty subjects were observed for 191.7 patient-years. Eight had a single recurrent stroke (two intracranial hemorrhages and six infarctions) for a prevalence of 13.3%, or one recurrence for each 24 patient-years of observation. Thirteen subjects had 15 transient neurologic events; two of these had subsequent strokes, but the overall risk was similar for those who did and those did not have transient events. Hemoglobin S levels were greater than the desired maximum of 30% at the time of 7 of 16 transient events and five of six recurrent infarctions. The stroke recurrence rate was similar to those in previous reports of children receiving long-term transfusion therapy but significantly less than that reported for children who did not receive transfusions (p
ISSN:0022-3476
1097-6833
DOI:10.1016/S0022-3476(95)70204-0