Autoantibodies, mortality and ageing

Immunological failure may be the cause of predisposition to certain infections, neoplasms, and vascular diseases in adulthood. Mortality risks through life may reflect an undetermined number of causes. This study describes the prevalence of positivity of autoantibodies through life, along with gener...

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Bibliographic Details
Published in:Medical hypotheses 1995, Vol.44 (1), p.10-15
Main Authors: Richaud-Patin, Y., Villa, A.R.
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Aging - immunology
Americas - epidemiology
Autoantibodies - immunology
Biological and medical sciences
Diabetes Mellitus - immunology
Diabetes Mellitus - mortality
Diarrhea - immunology
Diarrhea - mortality
General aspects
Humans
Immunopathology
Leukemia - immunology
Leukemia - mortality
Medical sciences
Middle Aged
Mortality - trends
Neoplasms - immunology
Neoplasms - mortality
Prevalence
Risk Factors
Tuberculosis - immunology
Tuberculosis - mortality
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Summary:Immunological failure may be the cause of predisposition to certain infections, neoplasms, and vascular diseases in adulthood. Mortality risks through life may reflect an undetermined number of causes. This study describes the prevalence of positivity of autoantibodies through life, along with general and specific mortality causes in three countries with different socioeconomic development (Guatemala, Mexico and the United States). Prevalence of autoantibodies by age was obtained from previous reports. In spite of having involved different ethnic groups, the observed trends in prevalence of autoantibodies, as well as mortality through life, showed a similar behavior. Thus, both the increase in autoantibody production and death risk as age rises, may share physiopathological phenomena related to the ageing process.
ISSN:0306-9877
1532-2777
DOI:10.1016/0306-9877(95)90294-5