Telomere Shortening in Chronic Liver Diseases

We measured the telomere length in patients with chronic hepatitis or liver cirrhosis and found a significant telomere shortening in the liver with chronic liver disease compared to that in the normal liver. The telomere length tended to decrease with the progression of chronic liver disease.

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Bibliographic Details
Published in:Biochemical and biophysical research communications 1995-06, Vol.211 (1), p.33-39
Main Authors: Kitada, T., Seki, S., Kawakita, N., Kuroki, T., Monna, T.
Format: Article
Language:English
Subjects:
Adult
Aged
Aging - physiology
Base Sequence
Blotting, Southern
Female
Hepatitis - genetics
Hepatitis - pathology
Humans
Liver - cytology
Liver - metabolism
Liver - pathology
Liver Cirrhosis - genetics
Liver Cirrhosis - pathology
Liver Neoplasms - genetics
Liver Neoplasms - pathology
Liver Neoplasms - secondary
Male
Middle Aged
Molecular Sequence Data
Oligonucleotide Probes
Reference Values
Telomere - pathology
Telomere - ultrastructure
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Description
Summary:We measured the telomere length in patients with chronic hepatitis or liver cirrhosis and found a significant telomere shortening in the liver with chronic liver disease compared to that in the normal liver. The telomere length tended to decrease with the progression of chronic liver disease.
ISSN:0006-291X
1090-2104
DOI:10.1006/bbrc.1995.1774