Oncogenes in cancer of the pancreas

A three-step immunoperoxidase staining technique was used in order to estimate the immunohistochemical expression of K-ras, c-fos, c-myc and c-erbB-2 oncoproteins, in paraffin sections of 20 patients, with histologically proven adenocarcinoma of the pancreas. The two oncogenes that were found to be...

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Bibliographic Details
Published in:European journal of surgical oncology 1995-06, Vol.21 (3), p.251-253
Main Authors: Sakorafas, G.H., Lazaris, A., Tsiotou, A.G., Koullias, G., Glinatsis, M.T., Golematis, B.C.
Format: Article
Language:English
Subjects:
Adenocarcinoma - genetics
Adenocarcinoma - metabolism
Adenocarcinoma - surgery
Aged
Amino Acid Sequence
antioncogenes
Biological and medical sciences
cancer of the pancreas
Female
Gastroenterology. Liver. Pancreas. Abdomen
Gene Expression
Genes, erbB-2
Genes, fos
Genes, myc
Genes, ras
Humans
Immunoenzyme Techniques
Liver Neoplasms - metabolism
Liver Neoplasms - secondary
Liver. Biliary tract. Portal circulation. Exocrine pancreas
Lymph Nodes - metabolism
Lymphatic Metastasis
Male
Medical sciences
Middle Aged
Molecular Sequence Data
Oncogene Proteins - analysis
oncogenes
Pancreatic Neoplasms - genetics
Pancreatic Neoplasms - metabolism
Pancreatic Neoplasms - surgery
Proto-Oncogenes
Tumors
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Summary:A three-step immunoperoxidase staining technique was used in order to estimate the immunohistochemical expression of K-ras, c-fos, c-myc and c-erbB-2 oncoproteins, in paraffin sections of 20 patients, with histologically proven adenocarcinoma of the pancreas. The two oncogenes that were found to be associated with pancreatic adenocarcinoma were K-ras and c-erbB-2. The expression was observed in 15 patients (75%) and four patients (20%), respectively. Positive immunostaining was intense, cytoplasmic and was noted in a great percentage of cancer cells. The same model of expression was observed in the examined cases of metastatic tissue from liver and lymph node metastases. The expression of myc and fos oncogenes was nuclear, weak and was observed in a small number of patients.
ISSN:0748-7983
1532-2157
DOI:10.1016/S0748-7983(95)91294-0