Free radical scavengers prevent reflux esophagitis in rats

Free radical damage in reflux esophagitis of rats induced by 24-hr duodenojejunal ligation was studied. Oxygen free radicals were selectively blocked. Groups were: sham operation, reflux, reflux + superoxide dismutase (SOD), catalase, dimethylthiourea, allopurinol, and inactivated SOD or inactivated...

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Published in:Digestive diseases and sciences 1995-06, Vol.40 (6), p.1292-1296
Main Authors: WETSCHER, G. J, HINDER, P. R, BAGGHI, D, PERDIKIS, G, REDMOND, E. J, GLASER, K, ADRIAN, T. E, HINDER, R. A
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Disease Models, Animal
Drug Evaluation, Preclinical
Drug Therapy, Combination
Esophagitis, Peptic - metabolism
Esophagitis, Peptic - prevention & control
Esophagus - drug effects
Esophagus - metabolism
Free Radical Scavengers - therapeutic use
Free Radicals - metabolism
Gastroenterology. Liver. Pancreas. Abdomen
Glutathione - metabolism
Linear Models
Lipid Peroxidation - drug effects
Male
Medical sciences
Mucous Membrane - drug effects
Mucous Membrane - metabolism
Other diseases. Semiology
Oxygen Consumption - drug effects
Rats
Rats, Sprague-Dawley
Statistics, Nonparametric
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
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Summary:Free radical damage in reflux esophagitis of rats induced by 24-hr duodenojejunal ligation was studied. Oxygen free radicals were selectively blocked. Groups were: sham operation, reflux, reflux + superoxide dismutase (SOD), catalase, dimethylthiourea, allopurinol, and inactivated SOD or inactivated catalase alone or in the combination SOD + catalase or SOD + catalase + dimethylthiourea + allopurinol. Macroscopic esophagitis was inhibited only by SOD, alone or in combination with other agents. Esophageal mucosal lipid peroxidation was 10-fold increased in the reflux group compared to the sham group (P < 0.05). This response was damped by SOD > catalase (P < 0.05) but not by the inactivated enzymes, dimethylthiourea or allopurinol. SOD + catalase showed no significant improvement on SOD alone. Total inhibition of lipid peroxidation was achieved by combining all scavengers. Total glutathione (GSH) in the esophageal mucosa was stimulated by reflux. This response was inhibited by scavengers equivalent to their efficacy in preventing lipid peroxidation. It is concluded that reflux esophagitis is associated with free radical release with O2- being the main source. Free radicals appear to stimulate GSH production in this prolonged oxidative stress.
ISSN:0163-2116
1573-2568
DOI:10.1007/BF02065541