Apoptosis regulatory gene NEDD2 maps to human chromosome segment 7q34-35, a region frequently affected in haematological neoplasms

Developmentally regulated mouse gene Nedd2 encodes a protein similar to the product of the nematode Caenorhabditis elegans cell death gene ced-3 and the mammalian interleukin-1 beta-converting enzyme. Overexpression of Nedd2 in cultured mammalian cells induces apoptosis that can be blocked by proto-...

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Bibliographic Details
Published in:Human genetics 1995-06, Vol.95 (6), p.641-644
Main Authors: SHARAD KUMAR, WHITE, D. L, TAKAI, S, TURCZYNOWICZ, S, JUTTNER, C. A, HUGHES, T. P
Format: Article
Language:English
Subjects:
apoptosis
Apoptosis - genetics
BCL2 gene
Biological and medical sciences
Blood Cells - pathology
Caenorhabditis elegans
Caspase 2
chromosome 7
Chromosome Mapping
Chromosomes, Human, Pair 7 - genetics
Classical genetics, quantitative genetics, hybrids
Cysteine Endopeptidases - genetics
fluorescence in situ hybridization
Fundamental and applied biological sciences. Psychology
Genes, Regulator - genetics
Genetics of eukaryotes. Biological and molecular evolution
hematological diseases
Human
Humans
In Situ Hybridization, Fluorescence
Leukemia - etiology
Leukemia - genetics
Lymphoma - etiology
Lymphoma - genetics
man
mice
NEDD2 gene
tumor suppressor genes
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Summary:Developmentally regulated mouse gene Nedd2 encodes a protein similar to the product of the nematode Caenorhabditis elegans cell death gene ced-3 and the mammalian interleukin-1 beta-converting enzyme. Overexpression of Nedd2 in cultured mammalian cells induces apoptosis that can be blocked by proto-oncogene BCL2. We have isolated cDNA clones for the human homologue of the mouse gene and, by using these as probes, mapped the human NEDD2 gene to 7q34-35 by fluorescence in situ hybridisation. The potential tumour suppressor function of NEDD2 is discussed.
ISSN:0340-6717
1432-1203
DOI:10.1007/BF00209480