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Human influenza virus recognition of sialyloligosaccharides

Sialic acids are essential components of cell-surface receptors utilized by influenza viruses. To evaluate the recognition of asialic sugar parts of the receptor, three representative strains of human influenza A and B viruses were tested for their binding of a panel of sialyloligosaccharides. The h...

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Bibliographic Details
Published in:FEBS letters 1995-06, Vol.366 (1), p.57-60
Main Authors: Gambaryan, A.S., Piskarev, V.E., Yamskov, I.A., Sakharov, A.M., Tuzikov, A.B., Bovin, N.V., Nifant'ev, N.E., Matrosovich, M.N.
Format: Article
Language:English
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Summary:Sialic acids are essential components of cell-surface receptors utilized by influenza viruses. To evaluate the recognition of asialic sugar parts of the receptor, three representative strains of human influenza A and B viruses were tested for their binding of a panel of sialyloligosaccharides. The highest affinity binding carbohydrate determinants recognized by the viruses in a context of different core structures were Neu5Acα2-3Gal for the type B virus, Neu5Acα2-6Gal for the H3 subtype virus, and Neu5Acα2-6Ga/β1-4GlcNAc for the H1 subtype virus. Penultimate to these determinants parts of sialyloligosaccharides studied either contributed less significantly to the binding affinity, or interfered with the binding.
ISSN:0014-5793
1873-3468
DOI:10.1016/0014-5793(95)00488-U