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Human influenza virus recognition of sialyloligosaccharides
Sialic acids are essential components of cell-surface receptors utilized by influenza viruses. To evaluate the recognition of asialic sugar parts of the receptor, three representative strains of human influenza A and B viruses were tested for their binding of a panel of sialyloligosaccharides. The h...
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Published in: | FEBS letters 1995-06, Vol.366 (1), p.57-60 |
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Main Authors: | , , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | Sialic acids are essential components of cell-surface receptors utilized by influenza viruses. To evaluate the recognition of asialic sugar parts of the receptor, three representative strains of human influenza A and B viruses were tested for their binding of a panel of sialyloligosaccharides. The highest affinity binding carbohydrate determinants recognized by the viruses in a context of different core structures were Neu5Acα2-3Gal for the type B virus, Neu5Acα2-6Gal for the H3 subtype virus, and Neu5Acα2-6Ga/β1-4GlcNAc for the H1 subtype virus. Penultimate to these determinants parts of sialyloligosaccharides studied either contributed less significantly to the binding affinity, or interfered with the binding. |
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ISSN: | 0014-5793 1873-3468 |
DOI: | 10.1016/0014-5793(95)00488-U |