Effects of alpha,beta-unsaturated sulphones and phosphonium salts on ecto-ATPase activity and contractile responses mediated via P2 chi-purinoceptors

1. In the guinea-pig urinary bladder and vas deferens, several alpha,beta-unsaturated sulphones and phosphonium salts that were tested inhibited ecto-ATPase activity. The sulphones were more active in the bladder but the phosphonium salts were more effective in the vas deferens. 2. These compounds e...

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Bibliographic Details
Published in:General pharmacology 1995-05, Vol.26 (3), p.527-532
Main Authors: Ziganshin, A U, Berdnikov, E A, Ziganshina, L E, Tantasheva, F R, Hoyle, C H, Burnstock, G
Format: Article
Language:English
Subjects:
Adenosine Triphosphatases - metabolism
Animals
Cell Membrane - drug effects
Cell Membrane - enzymology
Guinea Pigs
In Vitro Techniques
Male
Muscle Contraction - drug effects
Muscle, Smooth - drug effects
Muscle, Smooth - enzymology
Organophosphorus Compounds - pharmacology
Receptors, Purinergic P2 - drug effects
Sulfones - pharmacology
Synaptic Transmission - drug effects
Urinary Bladder - drug effects
Urinary Bladder - enzymology
Vas Deferens - drug effects
Vas Deferens - enzymology
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Summary:1. In the guinea-pig urinary bladder and vas deferens, several alpha,beta-unsaturated sulphones and phosphonium salts that were tested inhibited ecto-ATPase activity. The sulphones were more active in the bladder but the phosphonium salts were more effective in the vas deferens. 2. These compounds either potentiated or inhibited purinergic contractile responses in the guinea-pig urinary bladder and vas deferens. 3. alpha,beta-Unsaturated sulphones and phosphonium salts represent a new promising class of compounds, capable of modulating purinergic neurotransmission.
ISSN:0306-3623