Adenosine triphosphate and arachidonic acid stimulate glycogenolysis in primary cultures of mouse cerebral cortical astrocytes

Adenosine triphosphate (ATP) promotes glycogenolysis in primary cultures of mouse cerebral cortical astrocytes with an EC 50 of 1.5 μM. A pharmacological analysis indicates an involvement of purinergic P 2Y receptors in this action of ATP Application of either arachidonic acid (AA), or certain unsat...

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Bibliographic Details
Published in:Neuroscience letters 1995-03, Vol.188 (2), p.109-112
Main Authors: Sorg, Olivier, Pellerin, Luc, Stolz, Marc, Beggah, Siham, Magistretti, Pierre J.
Format: Article
Language:English
Subjects:
Adenosine Triphosphate - pharmacology
Animals
Arachidonic acid
Arachidonic Acid - pharmacology
Astrocytes
Astrocytes - metabolism
ATP
Biological and medical sciences
Cells, Cultured
Cerebral Cortex - cytology
Cerebral Cortex - metabolism
Energy metabolism
Fundamental and applied biological sciences. Psychology
Glycogen
Glycogen - metabolism
Isolated neuron and nerve. Neuroglia
Mice
Mice, Inbred Strains
Purinergic
Receptors, Purinergic - physiology
Vertebrates: nervous system and sense organs
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Summary:Adenosine triphosphate (ATP) promotes glycogenolysis in primary cultures of mouse cerebral cortical astrocytes with an EC 50 of 1.5 μM. A pharmacological analysis indicates an involvement of purinergic P 2Y receptors in this action of ATP Application of either arachidonic acid (AA), or certain unsaturated fatty acids, also results in glycogen breakdown. The EC 50 of AA is approximately 50 μM. Thus ATP and AA can be added to the list of neuroactive agents that control glycogen levels in astrocytes, which includes noradrenaline, vasoactive intestinal peptide (VIP), adenosine and histamine.
ISSN:0304-3940
1872-7972
DOI:10.1016/0304-3940(95)11410-X