An Arbovirus Cline across the Northern Hemisphere

The mode and tempo of arbovirus evolution and dispersal can help to explain the dynamics of pandemics, viral outbreaks, and emerging viruses. By comparing nucleotide and deduced amino acid sequences of their envelope proteins, we describe the continuous distribution of the tick-borne encephalitis (T...

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Bibliographic Details
Published in:Virology (New York, N.Y.) N.Y.), 1995-06, Vol.210 (1), p.152-159
Main Authors: de A. Zanotto, P.M., Gao, G.F., Gritsun, T., Marin, M.S., Jiang, W.R., Venugopal, K., Reid, H.W., Gould, E.A.
Format: Article
Language:English
Subjects:
Animals
Arboviruses - classification
Arboviruses - genetics
Base Sequence
Biological Evolution
Codon
Culicidae - virology
Flavivirus - classification
Flavivirus - genetics
Geography
Models, Genetic
Molecular Sequence Data
Phylogeny
Probability
tick-borne encephalitis virus
Ticks - virology
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Description
Summary:The mode and tempo of arbovirus evolution and dispersal can help to explain the dynamics of pandemics, viral outbreaks, and emerging viruses. By comparing nucleotide and deduced amino acid sequences of their envelope proteins, we describe the continuous distribution of the tick-borne encephalitis (TBE) complex viruses, the most important flaviviruses in Europe, across major geographical areas and the conditions under which mutations occur The analyses reveal a correlation between the geographical and genetic distances of these viruses, The arthropod host appears to be a key factor for the formation and maintenance of this cline by constraining TBE dispersal and evolution. This is also illustrated by comparisons with mosquito-borne flaviviruses.
ISSN:0042-6822
1096-0341
DOI:10.1006/viro.1995.1326