Effect of renal failure or portacaval shunt on release of neurotensin in man

Neurotensin-like immunoreactivity (NTLI) is released into the circulation following a meal. However, the factors influencing its degradation and metabolism are uncertain, but it is presumed that the kidneys and liver are involved. This study has determined the release of NTLI after a liquid fat meal...

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Bibliographic Details
Published in:Digestive diseases and sciences 1987, Vol.32 (1), p.28-32
Main Authors: EAVES, E. R, HANSKY, J
Format: Article
Language:English
Subjects:
Adolescent
Adult
Biological and medical sciences
Chromatography, High Pressure Liquid
Dietary Fats - administration & dosage
Dietary Fats - pharmacology
Humans
Kidney Failure, Chronic - metabolism
Liver, biliary tract, pancreas, portal circulation, spleen
Medical sciences
Middle Aged
Neuropeptides - metabolism
Neurotensin - metabolism
Portacaval Shunt, Surgical
Radioimmunoassay
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Surgery of the digestive system
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Summary:Neurotensin-like immunoreactivity (NTLI) is released into the circulation following a meal. However, the factors influencing its degradation and metabolism are uncertain, but it is presumed that the kidneys and liver are involved. This study has determined the release of NTLI after a liquid fat meal (200 ml 20% Intralipid) in 10 healthy control subjects, five patients with stable chronic renal failure (CRF), and five patients after a portacaval shunt (PCS), to assess the possible role of the liver and kidney in NTLI metabolism. NTLI was measured by radioimmunoassay using both specific C and N terminally directed antisera. The results showed: Basal NTLI levels are similar in controls, after PCS, and in CRF. A liquid fat meal produces a single early peak of NTLI and levels are greater after PCS than in controls or CRF. Levels return much more slowly to basal in CRF and after PCS. Thus it is likely that both the liver and kidney are involved in the metabolism and clearance of NTLI.
ISSN:0163-2116
1573-2568
DOI:10.1007/BF01296684