Hercon Technology for Transdermal Delivery of Drugs

The Hercon controlled drug delivery technology is based on a multi-layered laminated polymeric structure, in which a layer of vinyl chloride copolymer or terpolymer containing the drug is sandwiched between two or more layers of polymeric films. The drug is released from the device at a controlled r...

Full description

Saved in:
Bibliographic Details
Published in:Journal of biomaterials applications 1986, Vol.1 (2), p.239-273
Main Authors: Shah, Kishore R., Ng, Shirley, Zeoli, Laura, Haight, Valerie, Matz, Sheila, Kydonieus, Agis F.
Format: Article
Language:English
Subjects:
Administration, Cutaneous - instrumentation
Animals
Biological Availability
Clonidine - administration & dosage
Delayed-Action Preparations
Equipment Design
Estradiol - administration & dosage
Humans
Isosorbide Dinitrate - administration & dosage
Nitroglycerin - administration & dosage
Nitroglycerin - pharmacokinetics
Prostaglandins - administration & dosage
Scopolamine Hydrobromide - administration & dosage
Technology, Pharmaceutical
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The Hercon controlled drug delivery technology is based on a multi-layered laminated polymeric structure, in which a layer of vinyl chloride copolymer or terpolymer containing the drug is sandwiched between two or more layers of polymeric films. The drug is released from the device at a controlled rate by a process of diffusion through the reservoir and one of the outer layers, which can function as a rate controlling membrane. This basic technology has been successfully utilized for the development and commercialization of Nitroglycerin Transdermal System (NTS, Bolar Pharmaceutical Co., Inc). In vitro and in vivo investigations of transdermal delivery of different other drugs from the Hercon polymeric devices have indicated the feasibility of using this system to meet a variety of therapeutic needs.
ISSN:0885-3282
1530-8022
DOI:10.1177/088532828600100204