Transplantation of Skin from Human Immunodeficiency Virus Type 1-Transgenic Mice to Normal Congenic Mice Results in Graft Rejection

Skin from mice transgenic (Tg) for part of the human immunodeficiency virus type 1 (HIV-1) genome was transplanted onto normal mice of the same strain. All Tg grafts were rejected within 29 days. In contrast, skin from normal mice that was transplanted to HIV-1-Tg recipients remained viable for

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Bibliographic Details
Published in:The Journal of infectious diseases 1995-07, Vol.172 (1), p.232-234
Main Authors: Dumois, Juan A., VanderVegt, F. Pierre, Kopp, Jeffrey B., Marinos, Nancy J., Rooney, James F., Notkins, Abner Louis
Format: Article
Language:English
Subjects:
AIDS/HIV
Animals
Antigens
Biological and medical sciences
Concise Communications
Gene Deletion
Genome, Viral
Graft rejection
Graft Rejection - immunology
Graft Rejection - pathology
Graft Survival
HIV 1
HIV Envelope Protein gp120 - analysis
HIV Envelope Protein gp120 - biosynthesis
HIV-1 - genetics
HIV-1 - metabolism
human immunodeficiency virus
Immune tolerance
Immunodeficiencies
Immunodeficiencies. Immunoglobulinopathies
Immunopathology
Medical sciences
Mice
Mice, SCID
Mice, Transgenic
Papilloma
Skin
Skin grafts
Skin Transplantation - immunology
Skin Transplantation - pathology
Time Factors
Tissue grafting
Transgenic animals
Transplantation immunology
Transplantation, Homologous
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Description
Summary:Skin from mice transgenic (Tg) for part of the human immunodeficiency virus type 1 (HIV-1) genome was transplanted onto normal mice of the same strain. All Tg grafts were rejected within 29 days. In contrast, skin from normal mice that was transplanted to HIV-1-Tg recipients remained viable for
ISSN:0022-1899
1537-6613
DOI:10.1093/infdis/172.1.232