Immunohistochemical studies of blood group substance h in colorectal tumors using a monoclonal antibody

With the use of a murine monoclonal antibody with specificity for human blood group substance H, the distribution of this antigen on colorectal carcinomas and adenomatous polyps has been studied by immunohistochemistry. All of the 20 carcinomas studied were found to express H substance regardless of...

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Bibliographic Details
Published in:Cancer 1987-01, Vol.59 (1), p.118-127
Main Authors: Compton, Carolyn, Wyatt, Richard, Konugres, Angelyn, Ehrenthal, Deborah, Durda, Paul
Format: Article
Language:English
Subjects:
Adenocarcinoma - immunology
Adenoma - immunology
Antibodies, Monoclonal - biosynthesis
Blood Group Antigens - immunology
Colonic Neoplasms - immunology
Endothelium - immunology
Epitopes - immunology
Erythrocytes - immunology
Histocytochemistry
Humans
Immunoenzyme Techniques
Immunoglobulin M - biosynthesis
Intestinal Mucosa - immunology
Polyps - immunology
Rectal Neoplasms - immunology
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Summary:With the use of a murine monoclonal antibody with specificity for human blood group substance H, the distribution of this antigen on colorectal carcinomas and adenomatous polyps has been studied by immunohistochemistry. All of the 20 carcinomas studied were found to express H substance regardless of their location in the colon, their pathologic grade, or their clinical stage. Adenomas were variably positive for H substance, and expression of the antigen appeared to correlate with the degree of dysplasia seen on microscopic examination. Normal colonic mucosa, nonadenomatous polyps, and nonepithelial colonic neoplasms studied failed to express H substance. The results suggest that detection of H substance expression may be useful in the diagnosis of colonic malignancies and dysplastic premalignant lesions. Cancer 59:118–127, 1987.
ISSN:0008-543X
1097-0142
DOI:10.1002/1097-0142(19870101)59:1<118::AID-CNCR2820590125>3.0.CO;2-K