Use of ATR-FTIR spectroscopy to study the diffusion of ethanol through glycerogelatin films

The use of ATR-FTIR spectroscopy to study the permeability of a glycerogelatin film is described. Measurement of the diffusion coefficient of ethyl alcohol-d in the film showed excellent reproducibility. Comparison of results from this technique with those previously obtained using an air-flow recep...

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Bibliographic Details
Published in:Pharmaceutical research 1995-04, Vol.12 (4), p.572-575
Main Authors: TRALHAO, A. M. L, WATKINSON, A. C, BRAIN, K. R, HADGRAFT, J, ARMSTRONG, N. A
Format: Article
Language:English
Subjects:
Biological and medical sciences
Diffusion
Ethanol - chemistry
Gelatin
General pharmacology
Medical sciences
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Spectroscopy, Fourier Transform Infrared
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Summary:The use of ATR-FTIR spectroscopy to study the permeability of a glycerogelatin film is described. Measurement of the diffusion coefficient of ethyl alcohol-d in the film showed excellent reproducibility. Comparison of results from this technique with those previously obtained using an air-flow receptor phase diffusion cell show good agreement in terms of lag time assessed diffusion coefficients. ATR-FTIR spectroscopy revealed time-dependent changes in the composition of the glycerogelatin film during the diffusional process. It was also demonstrated that the concurrent assessment of both diffusant penetration and film composition is feasible.
ISSN:0724-8741
1573-904X
DOI:10.1023/A:1016262215192