Predominant affection of the blue cone pathway in Parkinson's disease

• Published in: Brain (London, England : 1878) England : 1878), 1995-06, Vol.118 (3), p.771-778
• Main Authors: Haug, Bernhard A., Kolle, Renate U., Trenkwalder, Claudia, Oertel, Wolfgang H., Paulus, Walter
• Format: Article
• Language: English
• Subjects: Aged; Biological and medical sciences; Color Vision Defects - etiology; Color Vision Defects - physiopathology; colour contrast; Cones; Contrast Sensitivity - physiology; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases; Differential Threshold; displacement thresholds; Dopamine - physiology; Female; Frequency dependence; Horizontal cells; Humans; luminance contrast; Male; Medical sciences; Middle Aged; Motion Perception; Movement disorders; Nerve Degeneration; Neurodegenerative diseases; Neurology; Parkinson Disease - complications; Parkinson Disease - drug therapy; Parkinson Disease - physiopathology; Parkinson's disease; Retinal Cone Photoreceptor Cells - physiopathology; Sensory Thresholds
• ISSN: 0006-8950; 1460-2156
• DOI: 10.1093/brain/118.3.771

Luminance contrast sensitivity and colour contrast thresholds were determined in 26 Parkinson patients and 17 normal controls of comparable age. They were psychophysically tested with a colour monitor system. Stimuli consisted of Gaussian enveloped luminance modulated or colour modulated (protan and tritan axis) vertical sine wave gratings with a spatial frequency of I cycle/°. The stimuli subtended 4° in diameter. Thresholds were determined using a two alternative forced choice method. Three different experimental conditions were explored: the detectability of stationary gratings, of moving gratings at velocities of 0, 2.5 and 5.0 cycles/s, and the detectability of horizontal square wave displacement at a frequency of 5 Hz for gratings of specified contrast levels. Intergroup differences were evaluated using two-tailed t tests with Satterthwaite corrections. Consistent and significant differences between normals and patients were found for tritan stimuli in the static and both dynamic conditions, and for luminance contrast stimuli in the displacement condition. Protan stimuli were much less apt to detect differences between the groups. We conclude that the retinal deficit of dopamine in Parkinson's disease is reflected in diminished centre/surround inhibition and that these changes are primarily apparent when vision is tested along the tritan axis, because blue cones are sparsely distributed.