Loading…
Sequence analysis of canine p53 in the region of exons 3–8
An 828 base pair region of canine wild-type p53, corresponding to codons 25 through 312 in the human p53 gene, was directly sequenced from asymmetric polymerase chain reaction (PCR) products. The deduced amino acid sequence of the dog was 86%, 73% and 83% homologous to that of the cat, mouse and hum...
Saved in:
| Published in: | Cancer letters 1995-06, Vol.92 (2), p.181-186 |
|---|---|
| Main Authors: | , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c417t-9ab8dccc263ab878d86ff5fd41e8534a74c195cc91e2452ea93ae7ffb785987f3 |
|---|---|
| cites | cdi_FETCH-LOGICAL-c417t-9ab8dccc263ab878d86ff5fd41e8534a74c195cc91e2452ea93ae7ffb785987f3 |
| container_end_page | 186 |
| container_issue | 2 |
| container_start_page | 181 |
| container_title | Cancer letters |
| container_volume | 92 |
| creator | Kraegel, Susan A. Pazzi, Karen A. Madewell, Bruce R. |
| description | An 828 base pair region of canine wild-type p53, corresponding to codons 25 through 312 in the human p53 gene, was directly sequenced from asymmetric polymerase chain reaction (PCR) products. The deduced amino acid sequence of the dog was 86%, 73% and 83% homologous to that of the cat, mouse and human proteins, respectively. In the evolutionarily conserved domains II through V, the canine sequence approached 100% homology with the human sequence. The region sequenced encompasses exons 3–8 where the majority of mutations have been identified in neoplastic specimens from human patients. |
| doi_str_mv | 10.1016/0304-3835(95)03779-V |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_77365628</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>030438359503779V</els_id><sourcerecordid>17060411</sourcerecordid><originalsourceid>FETCH-LOGICAL-c417t-9ab8dccc263ab878d86ff5fd41e8534a74c195cc91e2452ea93ae7ffb785987f3</originalsourceid><addsrcrecordid>eNqFkUtKBDEQhoMoOj5uoNALEV20Jp2kk4AIMvgCwYWPbcikKxrpSY9Jjzg77-ANPYndzjBLXVXB_1VRfIXQLsHHBJPyBFPMciopP1T8CFMhVP60ggZEiiIXSuJVNFgiG2gzpVeMMWeCr6N1UXZtoQbo9B7ephAsZCaYepZ8yhqXWRN8gGzCaeZD1r5AFuHZN6HP4KMJKaPfn19yG605UyfYWdQt9Hh58TC8zm_vrm6G57e5ZUS0uTIjWVlri5J2nZCVLJ3jrmIEJKfMCGaJ4tYqAgXjBRhFDQjnRkJyJYWjW-hgvncSm-7a1OqxTxbq2gRopkkLQUteFvJfkAhcYkZIB7I5aGOTUgSnJ9GPTZxpgnVvV_fqdK9OK65_7eqnbmxvsX86GkO1HFro7PL9RW6SNbWLJliflhjlShSs6LCzOQadtHcPUSfr-ydUPoJtddX4v-_4Ad68lP8</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>17060411</pqid></control><display><type>article</type><title>Sequence analysis of canine p53 in the region of exons 3–8</title><source>ScienceDirect Journals</source><creator>Kraegel, Susan A. ; Pazzi, Karen A. ; Madewell, Bruce R.</creator><creatorcontrib>Kraegel, Susan A. ; Pazzi, Karen A. ; Madewell, Bruce R.</creatorcontrib><description>An 828 base pair region of canine wild-type p53, corresponding to codons 25 through 312 in the human p53 gene, was directly sequenced from asymmetric polymerase chain reaction (PCR) products. The deduced amino acid sequence of the dog was 86%, 73% and 83% homologous to that of the cat, mouse and human proteins, respectively. In the evolutionarily conserved domains II through V, the canine sequence approached 100% homology with the human sequence. The region sequenced encompasses exons 3–8 where the majority of mutations have been identified in neoplastic specimens from human patients.</description><identifier>ISSN: 0304-3835</identifier><identifier>EISSN: 1872-7980</identifier><identifier>DOI: 10.1016/0304-3835(95)03779-V</identifier><identifier>PMID: 7600529</identifier><identifier>CODEN: CALEDQ</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Amino Acid Sequence ; Animals ; Base Sequence ; Biological and medical sciences ; Cats ; Classical genetics, quantitative genetics, hybrids ; Direct sequencing ; DNA - genetics ; DNA Primers ; Dog ; Dogs ; Exons ; Fundamental and applied biological sciences. Psychology ; Gene Amplification ; Genes, p53 ; Genetics of eukaryotes. Biological and molecular evolution ; Humans ; Mice ; Molecular Sequence Data ; p53 ; Polymerase Chain Reaction ; Sequence Analysis, DNA ; Sequence Homology, Amino Acid ; Species Specificity ; Tumor Suppressor Protein p53 - genetics ; Vertebrata</subject><ispartof>Cancer letters, 1995-06, Vol.92 (2), p.181-186</ispartof><rights>1995</rights><rights>1995 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-9ab8dccc263ab878d86ff5fd41e8534a74c195cc91e2452ea93ae7ffb785987f3</citedby><cites>FETCH-LOGICAL-c417t-9ab8dccc263ab878d86ff5fd41e8534a74c195cc91e2452ea93ae7ffb785987f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3597242$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7600529$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kraegel, Susan A.</creatorcontrib><creatorcontrib>Pazzi, Karen A.</creatorcontrib><creatorcontrib>Madewell, Bruce R.</creatorcontrib><title>Sequence analysis of canine p53 in the region of exons 3–8</title><title>Cancer letters</title><addtitle>Cancer Lett</addtitle><description>An 828 base pair region of canine wild-type p53, corresponding to codons 25 through 312 in the human p53 gene, was directly sequenced from asymmetric polymerase chain reaction (PCR) products. The deduced amino acid sequence of the dog was 86%, 73% and 83% homologous to that of the cat, mouse and human proteins, respectively. In the evolutionarily conserved domains II through V, the canine sequence approached 100% homology with the human sequence. The region sequenced encompasses exons 3–8 where the majority of mutations have been identified in neoplastic specimens from human patients.</description><subject>Amino Acid Sequence</subject><subject>Animals</subject><subject>Base Sequence</subject><subject>Biological and medical sciences</subject><subject>Cats</subject><subject>Classical genetics, quantitative genetics, hybrids</subject><subject>Direct sequencing</subject><subject>DNA - genetics</subject><subject>DNA Primers</subject><subject>Dog</subject><subject>Dogs</subject><subject>Exons</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene Amplification</subject><subject>Genes, p53</subject><subject>Genetics of eukaryotes. Biological and molecular evolution</subject><subject>Humans</subject><subject>Mice</subject><subject>Molecular Sequence Data</subject><subject>p53</subject><subject>Polymerase Chain Reaction</subject><subject>Sequence Analysis, DNA</subject><subject>Sequence Homology, Amino Acid</subject><subject>Species Specificity</subject><subject>Tumor Suppressor Protein p53 - genetics</subject><subject>Vertebrata</subject><issn>0304-3835</issn><issn>1872-7980</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><recordid>eNqFkUtKBDEQhoMoOj5uoNALEV20Jp2kk4AIMvgCwYWPbcikKxrpSY9Jjzg77-ANPYndzjBLXVXB_1VRfIXQLsHHBJPyBFPMciopP1T8CFMhVP60ggZEiiIXSuJVNFgiG2gzpVeMMWeCr6N1UXZtoQbo9B7ephAsZCaYepZ8yhqXWRN8gGzCaeZD1r5AFuHZN6HP4KMJKaPfn19yG605UyfYWdQt9Hh58TC8zm_vrm6G57e5ZUS0uTIjWVlri5J2nZCVLJ3jrmIEJKfMCGaJ4tYqAgXjBRhFDQjnRkJyJYWjW-hgvncSm-7a1OqxTxbq2gRopkkLQUteFvJfkAhcYkZIB7I5aGOTUgSnJ9GPTZxpgnVvV_fqdK9OK65_7eqnbmxvsX86GkO1HFro7PL9RW6SNbWLJliflhjlShSs6LCzOQadtHcPUSfr-ydUPoJtddX4v-_4Ad68lP8</recordid><startdate>19950608</startdate><enddate>19950608</enddate><creator>Kraegel, Susan A.</creator><creator>Pazzi, Karen A.</creator><creator>Madewell, Bruce R.</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TM</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>19950608</creationdate><title>Sequence analysis of canine p53 in the region of exons 3–8</title><author>Kraegel, Susan A. ; Pazzi, Karen A. ; Madewell, Bruce R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-9ab8dccc263ab878d86ff5fd41e8534a74c195cc91e2452ea93ae7ffb785987f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Amino Acid Sequence</topic><topic>Animals</topic><topic>Base Sequence</topic><topic>Biological and medical sciences</topic><topic>Cats</topic><topic>Classical genetics, quantitative genetics, hybrids</topic><topic>Direct sequencing</topic><topic>DNA - genetics</topic><topic>DNA Primers</topic><topic>Dog</topic><topic>Dogs</topic><topic>Exons</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gene Amplification</topic><topic>Genes, p53</topic><topic>Genetics of eukaryotes. Biological and molecular evolution</topic><topic>Humans</topic><topic>Mice</topic><topic>Molecular Sequence Data</topic><topic>p53</topic><topic>Polymerase Chain Reaction</topic><topic>Sequence Analysis, DNA</topic><topic>Sequence Homology, Amino Acid</topic><topic>Species Specificity</topic><topic>Tumor Suppressor Protein p53 - genetics</topic><topic>Vertebrata</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kraegel, Susan A.</creatorcontrib><creatorcontrib>Pazzi, Karen A.</creatorcontrib><creatorcontrib>Madewell, Bruce R.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kraegel, Susan A.</au><au>Pazzi, Karen A.</au><au>Madewell, Bruce R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sequence analysis of canine p53 in the region of exons 3–8</atitle><jtitle>Cancer letters</jtitle><addtitle>Cancer Lett</addtitle><date>1995-06-08</date><risdate>1995</risdate><volume>92</volume><issue>2</issue><spage>181</spage><epage>186</epage><pages>181-186</pages><issn>0304-3835</issn><eissn>1872-7980</eissn><coden>CALEDQ</coden><abstract>An 828 base pair region of canine wild-type p53, corresponding to codons 25 through 312 in the human p53 gene, was directly sequenced from asymmetric polymerase chain reaction (PCR) products. The deduced amino acid sequence of the dog was 86%, 73% and 83% homologous to that of the cat, mouse and human proteins, respectively. In the evolutionarily conserved domains II through V, the canine sequence approached 100% homology with the human sequence. The region sequenced encompasses exons 3–8 where the majority of mutations have been identified in neoplastic specimens from human patients.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>7600529</pmid><doi>10.1016/0304-3835(95)03779-V</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0304-3835 |
| ispartof | Cancer letters, 1995-06, Vol.92 (2), p.181-186 |
| issn | 0304-3835 1872-7980 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_77365628 |
| source | ScienceDirect Journals |
| subjects | Amino Acid Sequence Animals Base Sequence Biological and medical sciences Cats Classical genetics, quantitative genetics, hybrids Direct sequencing DNA - genetics DNA Primers Dog Dogs Exons Fundamental and applied biological sciences. Psychology Gene Amplification Genes, p53 Genetics of eukaryotes. Biological and molecular evolution Humans Mice Molecular Sequence Data p53 Polymerase Chain Reaction Sequence Analysis, DNA Sequence Homology, Amino Acid Species Specificity Tumor Suppressor Protein p53 - genetics Vertebrata |
| title | Sequence analysis of canine p53 in the region of exons 3–8 |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-05T00%3A17%3A08IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Sequence%20analysis%20of%20canine%20p53%20in%20the%20region%20of%20exons%203%E2%80%938&rft.jtitle=Cancer%20letters&rft.au=Kraegel,%20Susan%20A.&rft.date=1995-06-08&rft.volume=92&rft.issue=2&rft.spage=181&rft.epage=186&rft.pages=181-186&rft.issn=0304-3835&rft.eissn=1872-7980&rft.coden=CALEDQ&rft_id=info:doi/10.1016/0304-3835(95)03779-V&rft_dat=%3Cproquest_cross%3E17060411%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c417t-9ab8dccc263ab878d86ff5fd41e8534a74c195cc91e2452ea93ae7ffb785987f3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=17060411&rft_id=info:pmid/7600529&rfr_iscdi=true |