Association of Helicobacter pylori and gastric autoimmunity: A population‐based study

Based on clinical studies, a negative association between Helicobacter pylori and autoimmune corpus gastritis is described. In the present investigation of an unselected population of 1461 adults we can state, however, that there exists a relationship between H. pylori infection and the development...

Full description

Saved in:
Bibliographic Details
Published in:FEMS immunology and medical microbiology 1995-03, Vol.11 (1), p.65-68
Main Authors: Uibo, Raivo, Vorobjova, Tamara, Metsküla, Kaja, Kisand, Kalle, Wadström, Torkel, Kivik, Tiiu
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Amino Acid Sequence
Animals
Antigens, Bacterial - genetics
Autoantibodies - blood
Autoantigens - genetics
Autoimmune Diseases - microbiology
Bacterial diseases
Bacterial diseases of the digestive system and abdomen
Biological and medical sciences
Chronic gastritis
Cohort Studies
Estonia
Female
Gastric autoimmunity
Gastritis - immunology
Gastritis - microbiology
Gastroenterology. Liver. Pancreas. Abdomen
H(+)-K(+)-Exchanging ATPase - genetics
Helicobacter Infections - immunology
Helicobacter pylori
Human bacterial diseases
Humans
IgG antibody
Immunoglobulin G - blood
Infectious diseases
Male
Medical sciences
Mice
Middle Aged
Molecular Sequence Data
Other diseases. Semiology
Parietal cell antibody
Parietal Cells, Gastric - enzymology
Parietal Cells, Gastric - immunology
Rats
Sequence Homology, Amino Acid
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
Urease - genetics
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Based on clinical studies, a negative association between Helicobacter pylori and autoimmune corpus gastritis is described. In the present investigation of an unselected population of 1461 adults we can state, however, that there exists a relationship between H. pylori infection and the development of gastric corpus autoimmunity. As confirmation for the gastric autoantibody development through molecular mimicry, a high homology (72% in 25 amino acid overlap) between the beta subunit of H. pylori urease and that of H + K + ATPase, the gastric parietal cell autoantigen, was revealed.
ISSN:0928-8244
1574-695X
DOI:10.1111/j.1574-695X.1995.tb00079.x