Phenamide, a Fungicidal Metabolite from Streptomyces albospinus A19301: Taxonomy, Fermentation, Isolation, Physico-chemical and Biological Properties

A new derivative of phenylalanine, phenamide, was discovered from the fermentation broth of an actinomycete identified as a member of the Streptomyces albospinus cluster. Phenamide was purified using successive CIS reverse phase and cation exchange chromatography. Its structure was determined by spe...

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Bibliographic Details
Published in:Journal of antibiotics 1995/05/25, Vol.48(5), pp.369-374
Main Authors: MAKKAR, NARINDER S., NICKSON, THOMAS E., TRAN, MINHTIEN, BIEST, NANCY, MILLER-WIDEMAN, MARGARET, LAWSON, JON, MCGARY, CAROLYN I., STONARD, RICHARD
Format: Article
Language:English
Subjects:
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antifungal agents
Antifungal Agents - chemistry
Antifungal Agents - isolation & purification
Antifungal Agents - pharmacology
Biological and medical sciences
Fermentation
Medical sciences
Microbial Sensitivity Tests
Pharmacology. Drug treatments
Phenylalanine - analogs & derivatives
Phenylalanine - chemistry
Phenylalanine - isolation & purification
Phenylalanine - pharmacology
Septoria nodorum
Streptomyces - metabolism
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Summary:A new derivative of phenylalanine, phenamide, was discovered from the fermentation broth of an actinomycete identified as a member of the Streptomyces albospinus cluster. Phenamide was purified using successive CIS reverse phase and cation exchange chromatography. Its structure was determined by spectroscopic and chemical methods. Its molecular formula, C14H20N2O3, was determined by HRFAB-MS. Phenamide showed activity against Septoria nodorum, the causal agent of wheat glume blotch.
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.48.369