Sarcomatoid renal cell carcinoma: Clinicopathologic. A study of 42 cases

Forty‐two cases of sarcomatoid renal cell carcinoma were reviewed clinicopathologically. Twenty‐four patients were men, and 18 women; average age was 56.2 years (range, 30–81 years). Eight, 9, 13, and 12 cases were Stages I, II, III, and IV, respectively. Three morphologic patterns of sarcomatoid co...

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Bibliographic Details
Published in:Cancer 1987-02, Vol.59 (3), p.516-526
Main Authors: Ro, Jae Y., Ayala, Alberto G., Sella, Avishay, Samuels, Melvin L., Swanson, David A.
Format: Article
Language:English
Subjects:
Biological and medical sciences
Carcinoma, Renal Cell - classification
Carcinoma, Renal Cell - pathology
Female
Humans
Kidney Neoplasms - classification
Kidney Neoplasms - pathology
Kidneys
Male
Medical sciences
Necrosis
Nephrology. Urinary tract diseases
Prognosis
Sarcoma - pathology
Tumors of the urinary system
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Summary:Forty‐two cases of sarcomatoid renal cell carcinoma were reviewed clinicopathologically. Twenty‐four patients were men, and 18 women; average age was 56.2 years (range, 30–81 years). Eight, 9, 13, and 12 cases were Stages I, II, III, and IV, respectively. Three morphologic patterns of sarcomatoid components were identified: malignant fibrous histiocytomatous (26 cases), fibrosarcomatous (6 cases), and unclassified sarcomatoid (10 cases). Mitotic count, degree of pleomorphism, cellularity, and amount of tumor matrix in the sarcomatoid areas, and similar morphologic parameters in the carcinomatous component all failed to correlate with prognosis, as did tumor size and renal vein involvement by tumor. Clinicopathologic stage was a most significant prognostic factor, with a survival of 49.7 months for Stage I and 6.8 months for combined Stages II, III, and IV. Tumor necrosis in the sarcomatoid area and proportion of sarcomatoid components were also poor prognostic factors. When these factors were compared to the stage, necrosis was an independent variable, however, proportion of sarcomatoid components was a poor prognostic indicator only for Stages I and II.
ISSN:0008-543X
1097-0142
DOI:10.1002/1097-0142(19870201)59:3<516::AID-CNCR2820590327>3.0.CO;2-W