Thoracotomy for pulmonary metastatic osteosarcoma. An analysis of prognostic indicators of survival

Removal of pulmonary metastases of osteosarcoma by thoracotomy is an accepted treatment; however, few investigators have analyzed the value of various prognostic factors in estimating survival. A review of all patients undergoing thoracotomy for recurrent osteosarcoma with pulmonary metastases treat...

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Bibliographic Details
Published in:Cancer 1987-01, Vol.59 (2), p.374-379
Main Authors: Meyer, William H., Schell, Michael J., Kumar, A. P. Mahesh, Rao, Bhaskar N., Green, Alexander A., Champion, John, Pratt, Charles B.
Format: Article
Language:English
Subjects:
Biological and medical sciences
Child
Clinical Trials as Topic
Female
Humans
Lung Neoplasms - secondary
Lung Neoplasms - surgery
Male
Medical sciences
Osteosarcoma - secondary
Osteosarcoma - surgery
Pneumology
Prognosis
Retrospective Studies
Sex Factors
Thoracic Surgery
Tumors of the respiratory system and mediastinum
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Summary:Removal of pulmonary metastases of osteosarcoma by thoracotomy is an accepted treatment; however, few investigators have analyzed the value of various prognostic factors in estimating survival. A review of all patients undergoing thoracotomy for recurrent osteosarcoma with pulmonary metastases treated at St. Jude Children's Research Hospital is reported. Since 1968, two thirds (39/59) of all patients who developed pulmonary metastases have had a total of 66 thoracotomies. Nine patients are alive with no evidence of disease, and six additional patients are alive with disease. Analyzed in 39 evaluable patients, the prognostic factors that correlate with survival by univariate analysis are: sex, number of nodules detected radiographically and resected, completeness of resection, and tumor location (bilateral versus unilateral). By Cox regression analysis, only sex and the number of nodules detected either radiographically or during surgery, and resected, had statistically significant correlation with survival. Thoracotomy is curative for some patients with pulmonary metastatic osteosarcoma and Prognostic factors predictive for survival are defined. Cancer 59:374–379, 1987.
ISSN:0008-543X
1097-0142
DOI:10.1002/1097-0142(19870115)59:2<374::AID-CNCR2820590235>3.0.CO;2-6