Compartmentalization of Cells Bearing “Rheumatic” Cell Surface Antigens in Peripheral Blood and Tonsils in Rheumatic Heart Disease

Monoclonal antibodies that recognize “rheumatic” antigens of peripheral blood non-T cells were used to study the compartmentalization of such cells in peripheral blood and tonsils of individuals with rheumatic heart disease (RHD) and suitable control subjects. The peripheral blood of most (71%) of t...

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Bibliographic Details
Published in:The Journal of infectious diseases 1987-02, Vol.155 (2), p.247-252
Main Authors: Gray, E. D., Regelmann, W. E., Abdin, Z., Kholy, A. EI, Zaher, S., Kamel, R., Mansour, M., Miller, L., Ferrieri, P., Zabriskie, J. B., Braun, D.
Format: Article
Language:English
Subjects:
Adolescent
Antibodies
Antigens
Antigens, Surface - analysis
B lymphocytes
Bacterial diseases
Biological and medical sciences
Blood
Child
Control groups
Heart diseases
Human bacterial diseases
Humans
Infectious diseases
Lymphocytes - immunology
Medical sciences
Monoclonal antibodies
Original Articles
Palatine Tonsil - immunology
Palatine tonsils
Rheumatic heart disease
Rheumatic Heart Disease - blood
Rheumatic Heart Disease - immunology
Staphylococcal infections, streptococcal infections, pneumococcal infections
T lymphocytes
Tonsillitis - blood
Tonsillitis - immunology
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Summary:Monoclonal antibodies that recognize “rheumatic” antigens of peripheral blood non-T cells were used to study the compartmentalization of such cells in peripheral blood and tonsils of individuals with rheumatic heart disease (RHD) and suitable control subjects. The peripheral blood of most (71%) of the 42 individuals with RHD contained cells reacting with monoclonal antibody 83S19.23 or 256S.10, whereas these cells were present in only 17% of the 41 control subjects (P < .02). However, none of 21 individuals with RHD had such cells in their tonsils, although they were present in the tonsils of 50% of the 40 control subjects (P < .03). These results may reflect a failure in RHD of organ-specific homing of cells with the epitopes recognized by the antibodies. The presence of these cells in tonsils may be important in the immune response to streptococcal pharyngeal infection, and their absence in RHD may be involved in the unusual immune responses characteristic of this disease.
ISSN:0022-1899
1537-6613
DOI:10.1093/infdis/155.2.247