The T4 Epitope is Not Required for a Normal Replicative Cycle of Human Immunodeficiency Virus

The authors report here that lymphocytes totally lacking in the OKT4 epitope but possessing another epitope (Leu 3) of the CD4 molecule are just as susceptible to HIV infections as are normal cells expressing the OKT4 epitope, in terms of the production of reverse transcriptase (RT), the kinetics of...

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Bibliographic Details
Published in:The Journal of infectious diseases 1987-03, Vol.155 (3), p.592-593
Main Authors: Folks, Thomas, Justement, Shawn, Mitchell, S. Ray, Cupps, Thomas R., Katz, Paul, Maples, John, Fauci, Anthony S.
Format: Article
Language:English
Subjects:
Adolescent
AIDS
AIDS/HIV
Antigens, Differentiation, T-Lymphocyte
Antigens, Surface - analysis
Correspondence
Epitopes
Female
HIV
HIV - physiology
human immunodeficiency virus
Humans
Infections
Lymphocytes
Molecules
Monoclonal antibodies
Retroviridae
T lymphocytes
T-Lymphocytes, Helper-Inducer - immunology
T-Lymphocytes, Helper-Inducer - microbiology
Virus Replication
Viruses
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Summary:The authors report here that lymphocytes totally lacking in the OKT4 epitope but possessing another epitope (Leu 3) of the CD4 molecule are just as susceptible to HIV infections as are normal cells expressing the OKT4 epitope, in terms of the production of reverse transcriptase (RT), the kinetics of viral infection, and CPE.
ISSN:0022-1899
1537-6613
DOI:10.1093/infdis/155.3.592