The T4 Epitope is Not Required for a Normal Replicative Cycle of Human Immunodeficiency Virus

The authors report here that lymphocytes totally lacking in the OKT4 epitope but possessing another epitope (Leu 3) of the CD4 molecule are just as susceptible to HIV infections as are normal cells expressing the OKT4 epitope, in terms of the production of reverse transcriptase (RT), the kinetics of...

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Published in:The Journal of infectious diseases 1987-03, Vol.155 (3), p.592-593
Main Authors: Folks, Thomas, Justement, Shawn, Mitchell, S. Ray, Cupps, Thomas R., Katz, Paul, Maples, John, Fauci, Anthony S.
Format: Article
Language:English
Subjects:
Adolescent
AIDS
AIDS/HIV
Antigens, Differentiation, T-Lymphocyte
Antigens, Surface - analysis
Correspondence
Epitopes
Female
HIV
HIV - physiology
human immunodeficiency virus
Humans
Infections
Lymphocytes
Molecules
Monoclonal antibodies
Retroviridae
T lymphocytes
T-Lymphocytes, Helper-Inducer - immunology
T-Lymphocytes, Helper-Inducer - microbiology
Virus Replication
Viruses
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container_end_page 593
container_issue 3
container_start_page 592
container_title The Journal of infectious diseases
container_volume 155
creator Folks, Thomas
Justement, Shawn
Mitchell, S. Ray
Cupps, Thomas R.
Katz, Paul
Maples, John
Fauci, Anthony S.
description The authors report here that lymphocytes totally lacking in the OKT4 epitope but possessing another epitope (Leu 3) of the CD4 molecule are just as susceptible to HIV infections as are normal cells expressing the OKT4 epitope, in terms of the production of reverse transcriptase (RT), the kinetics of viral infection, and CPE.
doi_str_mv 10.1093/infdis/155.3.592
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identifier ISSN: 0022-1899
ispartof The Journal of infectious diseases, 1987-03, Vol.155 (3), p.592-593
issn 0022-1899
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language eng
recordid cdi_proquest_miscellaneous_77380688
source Oxford University Press Archive
subjects Adolescent
AIDS
AIDS/HIV
Antigens, Differentiation, T-Lymphocyte
Antigens, Surface - analysis
Correspondence
Epitopes
Female
HIV
HIV - physiology
human immunodeficiency virus
Humans
Infections
Lymphocytes
Molecules
Monoclonal antibodies
Retroviridae
T lymphocytes
T-Lymphocytes, Helper-Inducer - immunology
T-Lymphocytes, Helper-Inducer - microbiology
Virus Replication
Viruses
title The T4 Epitope is Not Required for a Normal Replicative Cycle of Human Immunodeficiency Virus
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