Differential Expression of Fas Antigen and Bcl-2 Protein on CD4+ T Cells, CD8+ T Cells, and Monocytes

Fas antigen and Bcl-2 protein are considered to be involved in cellular homeostasis. We precisely analyzed the expression of human Fas antigen and Bcl-2 protein on CD4+ T cells, CD8+ T cells, and monocytes. The positivities of Fas antigen on CD4+ and CD8+ T cells increased with aging. In CD4+ T cell...

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Bibliographic Details
Published in:Cellular immunology 1995-07, Vol.163 (2), p.303-308
Main Authors: Shinohara, Satoshi, Sawada, Tetsuji, Nishioka, Yuichi, Tohma, Shigeto, Kisaki, Tomonari, Inoue, Tetsufumi, Ando, Kayo, Ikeda, Makoto, Fujii, Hitoshi, Ito, Koji
Format: Article
Language:English
Subjects:
Adult
AIDS/HIV
Antigens, Surface - biosynthesis
CD4-Positive T-Lymphocytes - immunology
CD4-Positive T-Lymphocytes - metabolism
CD8-Positive T-Lymphocytes - immunology
CD8-Positive T-Lymphocytes - metabolism
fas Receptor
Humans
Infant, Newborn
Leukocyte Common Antigens - biosynthesis
Middle Aged
Monocytes - metabolism
Proto-Oncogene Proteins - biosynthesis
Proto-Oncogene Proteins c-bcl-2
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Summary:Fas antigen and Bcl-2 protein are considered to be involved in cellular homeostasis. We precisely analyzed the expression of human Fas antigen and Bcl-2 protein on CD4+ T cells, CD8+ T cells, and monocytes. The positivities of Fas antigen on CD4+ and CD8+ T cells increased with aging. In CD4+ T cells, the Fas-/CD45RO+ subpopulation was dominant compared with the Fas+/CD45RO- subpopulation. Conversely, in CD8+ T cells, the Fas+/CD45RO- subpopulation was dominant compared with the Fas-/CD45RO+ subpopulation. Monocytes exhibited high positivity of Fas antigen and low fluorescence intensity of Bcl-2 protein compared with T cells. These results suggest that Fas antigen acts in different processes of cellular homeostasis between CD4+ and CD8+ T cells and that expression of Fas antigen and Bcl-2 protein is involved in homeostasis of monocytes as well as lymphocytes.
ISSN:0008-8749
1090-2163
DOI:10.1006/cimm.1995.1130