In Vitro Activation of the Antibacterial Activity of Human Pulmonary Macrophages by Recombinant γ Interferon

To determine whether IFN- gamma is capable of specifically activating antibacterial mechanisms in mononuclear phagocytes. The authors investigated the ability of recombinant IFN- gamma to restrict the growth of a representative intracellular bacterial parasite, Legionella pneumophila , in human pulm...

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Bibliographic Details
Published in:The Journal of infectious diseases 1987-03, Vol.155 (3), p.574-577
Main Authors: Jensen, William A., Rose, Richard M., Wasserman, Andrew S., Kalb, Thomas H., Anton, Kristen, Remold, Heinz G.
Format: Article
Language:English
Subjects:
Alveolar macrophages
Antibacterials
Bacteriology
Biological and medical sciences
Cells, Cultured
Concise Laboratory and Clinical Communications
Fundamental and applied biological sciences. Psychology
Humans
Infections
Infectious diseases
Interferon-gamma - pharmacology
Interferons
Legionella
Legionella - growth & development
Macrophages
Macrophages - immunology
Macrophages - microbiology
Microbiology
Pathogenicity, virulence, toxins, bacteriocins, pyrogens, host-bacteria relations, miscellaneous strains
Pathogens
Phagocytes
Pulmonary Alveoli
Recombinant Proteins - pharmacology
Smoking
T tests
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Summary:To determine whether IFN- gamma is capable of specifically activating antibacterial mechanisms in mononuclear phagocytes. The authors investigated the ability of recombinant IFN- gamma to restrict the growth of a representative intracellular bacterial parasite, Legionella pneumophila , in human pulmonary macrophages.
ISSN:0022-1899
1537-6613
DOI:10.1093/infdis/155.3.574