Proton spectroscopy of brain glutamine in acute liver failure

Evidence indicates that the accumulation of glutamine in the brain plays an important role in the pathogenesis and severity of the encephalopathy of acute liver failure (ALF). This study uses in vivo proton magnetic resonance spectroscopy ( H MRS) to assess brain glutamine (GLN) in five cases of acu...

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Bibliographic Details
Published in:Hepatology (Baltimore, Md.) Md.), 1995-07, Vol.22 (1), p.69-74
Main Authors: McConnell, James R., Antonson, Dean L., Ong, Chin Siong, Chu, Wei‐Kom, Fox, Ira J., Heffron, Thomas G., Langnas, Alan N., Shaw, Byers W.
Format: Article
Language:English
Subjects:
Acute Disease
Adolescent
Biological and medical sciences
Brain - metabolism
Brain Edema - etiology
Child
Feasibility Studies
Forecasting
Glutamine - metabolism
Hepatic Encephalopathy - etiology
Hepatic Encephalopathy - physiopathology
Humans
Infant
Investigative techniques, diagnostic techniques (general aspects)
Liver Failure - complications
Liver Failure - diagnosis
Liver Failure - metabolism
Magnetic Resonance Imaging
Magnetic Resonance Spectroscopy
Male
Medical sciences
Nervous system
Radiodiagnosis. Nmr imagery. Nmr spectrometry
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Summary:Evidence indicates that the accumulation of glutamine in the brain plays an important role in the pathogenesis and severity of the encephalopathy of acute liver failure (ALF). This study uses in vivo proton magnetic resonance spectroscopy ( H MRS) to assess brain glutamine (GLN) in five cases of acute liver failure. The findings are consistent with prior investigations and suggest that the alpha H of the GLN molecule can be used for noninvasive spectroscopic quantitation of brain GLN in patients with ALF. (HEPATOLOGY 1995;22:69–74.)
ISSN:0270-9139
1527-3350
DOI:10.1002/hep.1840220111