Renin, kallikrein and prostaglandin renal systems in normotensive boys with and without a family history of essential hypertension

The role of the kidney in the development of essential hypertension is subject of debate. We compared the renin, kallikrein and prostaglandin renal systems in two groups of normotensive boys, aged 7-16 years, with different degrees of risk for future hypertension: 27 had parents with essential hyper...

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Bibliographic Details
Published in:Journal of cardiovascular risk 1995-04, Vol.2 (2), p.143-145
Main Authors: Rey, C, Santos, F, Málaga, S, Orejas, G, Simarro, M, Crespo, M
Format: Article
Language:English
Subjects:
Adolescent
Blood Pressure
Case-Control Studies
Child
Creatinine - blood
Creatinine - urine
Dinoprostone - urine
Disease Susceptibility
Humans
Hypertension - etiology
Hypertension - genetics
Kallikreins - urine
Kidney - metabolism
Male
Physical Exertion
Posture
Renin - blood
Risk Factors
Sodium - urine
Supine Position
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Summary:The role of the kidney in the development of essential hypertension is subject of debate. We compared the renin, kallikrein and prostaglandin renal systems in two groups of normotensive boys, aged 7-16 years, with different degrees of risk for future hypertension: 27 had parents with essential hypertension and 12 had normotensive parents. Supine, standing and post-exercise plasma renin activity as well as levels of urinary kallikrein and prostaglandin E2 before and after exercise were measured. The ratio of post-exercise plasma renin activity (ng/ml/h) to 24 h urinary sodium excretion (mEq/kg/day) was lower in children with hypertensive parents (mean +/- SEM 1.86 +/- 0.24 compared with 3.62 +/- 0.94, P = 0.02). The boys with hypertensive parents had a lower ratio of urinary kallikrein to creatinine before (0.70 +/- 0.13 compared with 1.54 +/- 0.36, P = 0.01) and after exercise (0.80 +/- 0.13 compared with 1.35 +/- 0.23, P = 0.03). The ratio of urinary prostaglandin E2 to creatinine levels did not differ between the groups before or after exercise. The plasma renin activity response to exercise and urinary kallikrein excretion were decreased in boys at increased risk of future essential hypertension. These early abnormalities in the renin and kallikrein renal systems may be associated with the development of essential hypertension.
ISSN:1350-6277
DOI:10.1097/00043798-199504000-00010