Measurement of phthalates in small samples of mammalian tissue

Di-(2-ethylhexyl)-phthalate (DEHP) is a phhalic acid ester that is used as a plasticizer in polyvinyl chloride products, many of which have widespread medical application. Results of studies in this laboratory have suggested that there is an association between the absorption and deposition of DEHP...

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Bibliographic Details
Published in:Bulletin of environmental contamination and toxicology 1987-03, Vol.38 (3), p.363-368
Main Authors: ACOTT, P. D, MURPHY, M. G, OGBORN, M. R, CROCKER, J. F. S
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Chemical and industrial products toxicology. Toxic occupational diseases
Chromatography - methods
Diethylhexyl Phthalate - analysis
Kidney - analysis
Medical sciences
Phthalic Acids - analysis
Rats
Toxicology
Various organic compounds
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Summary:Di-(2-ethylhexyl)-phthalate (DEHP) is a phhalic acid ester that is used as a plasticizer in polyvinyl chloride products, many of which have widespread medical application. Results of studies in this laboratory have suggested that there is an association between the absorption and deposition of DEHP (and/or related chemicals) in the kidney and the acquired renal cystic disease (ACD) frequently seen in patients who have undergone prolonged dialysis treatment. In order to determine the relationship between the two, it has been necessary to establish a method for extracting and accurately quantitating minute amounts of these chemicals in small tissue samples. The authors bave now established such a method using kidneys from normal rats and from a rat model for ACD.
ISSN:0007-4861
1432-0800
DOI:10.1007/BF01606599