Mapping of the mouse Ly-6, Xp-14 and Gdc-1 loci to chromosome 15

• Published in: Immunogenetics (New York) 1987, Vol.25 (1), p.21-27
• Main Authors: HOGARTH, P. M, MCKENZIE, I. F. C, SUTTON, V. R, CURNOW, K. M, LEE, B. K, EICHER, E. M
• Format: Article
• Language: English
• Subjects: Alanine Transaminase - genetics; Animals; Antigens; Antigens, Ly - genetics; Biological and medical sciences; Chromosome Mapping; Crosses, Genetic; Fundamental and applied biological sciences. Psychology; Fundamental immunology; Genetic Linkage; Genetic Markers; Glycerolphosphate Dehydrogenase - genetics; Histocompatibility antigens (hla, h-2 and other systems); Mice - genetics; Mice, Inbred Strains - genetics; Molecular immunology; Polymorphism, Restriction Fragment Length
• ISSN: 0093-7711; 1432-1211
• DOI: 10.1007/BF00768829

The Ly-6 locus is now regarded as a gene complex consisting of at least five closely linked loci (Ly-6A-Ly-6E) whose polymorphic products are identified by monoclonal antibodies and distinguished by different tissue distributions. Ly-6 has been assigned by other investigators to chromosome (Chr) 9 (linked to Thy-1) or to Chr 2. We report that the Ly-6 gene complex, together with the Xp-14 and Gdc-1 loci, is situated on Chr 15 linked to Gpt-1. These new linkage data are derived from four sources: (1) three separate crosses that failed to demonstrate linkage of Ly-6 to either Thy-1 on Chr 9 or to any of five genes present on Chr 2; (2) the NXSM recombinant inbred strains, which suggested the linkage of Ly-6 and Xp-14 to Gpt-1 on Chr 15; (3) several Gpt-1 and Gdc-1 congenic strains that confirmed the assignment of Ly-6 and Xp-14 to Chr 15; and (4) backcrosses that further confirmed the linkage of Ly-6, Gpt-1, Gdc-1, and Xp-14, the probable gene order being Gpt-1/Ly-6-Xp-14-Gdc-1.