On safari with PrP: prion diseases of animals

Prions are infectious pathogens that cause fatal neurodegeneration in humans and animals and are composed largely, or entirely, of an aberrant isoform of the host-encoded prion protein (PrP). A post-translational process involving a conformational change in PrP is a significant feature of their repl...

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Bibliographic Details
Published in:Trends in Microbiology 1995-04, Vol.3 (4), p.141-147
Main Authors: Westaway, David, Carlson, George A., Prusiner, Stanley B.
Format: Article
Language:English
Subjects:
Animals
Prion Diseases - diagnosis
Prion Diseases - epidemiology
Prion Diseases - prevention & control
Prions - classification
Prions - genetics
Prions - pathogenicity
PrPC Proteins - genetics
PrPC Proteins - metabolism
PrPSc Proteins - genetics
PrPSc Proteins - metabolism
Scrapie - genetics
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Summary:Prions are infectious pathogens that cause fatal neurodegeneration in humans and animals and are composed largely, or entirely, of an aberrant isoform of the host-encoded prion protein (PrP). A post-translational process involving a conformational change in PrP is a significant feature of their replication. Differences in PrP sequences modify the incubation times, neuropathology and properties of prion ‘strains’.
ISSN:0966-842X
1878-4380
DOI:10.1016/S0966-842X(00)88903-9