The rat-pull test procedure: A method for assessing the strength of rats

A novel method for the measurement of rat strength is described. The method makes use of a rat's natural inclination to move forcibly and rapidly toward an enclosed, darkened compartment. Acrylamide (200.0 mg/kg, IP), gentamicin (30.0 mg/kg, IP), d-tubocurarine (0.1 mg/kg, IP), and diazepam (3....

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Bibliographic Details
Published in:Pharmacology, biochemistry and behavior biochemistry and behavior, 1995-04, Vol.50 (4), p.517-519
Main Authors: Giardina, William J., Wismer, Carol T.
Format: Article
Language:English
Subjects:
Acrylamide
Acrylamides - pharmacology
Animals
Biological and medical sciences
Diazepam - pharmacology
Drug toxicity and drugs side effects treatment
Ergometry - methods
Ergometry - veterinary
Evaluation Studies as Topic
Gentamicins - pharmacology
Grip strength
Male
Medical sciences
Muscle Contraction - drug effects
Muscle dysfunction
Pharmacology. Drug treatments
Rats
Rats, Sprague-Dawley
Reproducibility of Results
Sensitivity and Specificity
Strength
Toxicity: nervous system and muscle
Tubocurarine - pharmacology
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Summary:A novel method for the measurement of rat strength is described. The method makes use of a rat's natural inclination to move forcibly and rapidly toward an enclosed, darkened compartment. Acrylamide (200.0 mg/kg, IP), gentamicin (30.0 mg/kg, IP), d-tubocurarine (0.1 mg/kg, IP), and diazepam (3.0, 10.0, and 30.0 mg/kg, PO) significantly decreased strength. The rat-pull test procedure provides a sensitive, reliable, and valid method for the measurement of strength in rats.
ISSN:0091-3057
1873-5177
DOI:10.1016/0091-3057(94)00327-0