Influence of route of administration on progesterone metabolism

While inducing similar progesterone levels, the ratio of 5α- and 5β-pregnanolone/progesterone plasma concentrations has been dramatically increased after oral as opposed to vaginal administration, in a cross-over study. The known psychotropic effects of 5α- and 5β-pregnanolone lead to different indi...

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Bibliographic Details
Published in:Maturitas 1995-04, Vol.21 (3), p.251-257
Main Authors: de Lignieres, Bruno, Dennerstein, Lorraine, Backstrom, Torbjorn
Format: Article
Language:English
Subjects:
20-alpha-Dihydroprogesterone - blood
5α-pregnanolone
5β-pregnanolone
Administration, Intravaginal
Administration, Oral
Biological and medical sciences
Cross-Over Studies
Desoxycorticosterone - blood
Female
Hormones. Endocrine system
Humans
Medical sciences
Oral administration
Pharmacology. Drug treatments
Pregnanolone - blood
Progesterone - administration & dosage
Progesterone - blood
Progesterone - pharmacokinetics
Progestones
Vaginal administration
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Summary:While inducing similar progesterone levels, the ratio of 5α- and 5β-pregnanolone/progesterone plasma concentrations has been dramatically increased after oral as opposed to vaginal administration, in a cross-over study. The known psychotropic effects of 5α- and 5β-pregnanolone lead to different indications and precautions for oral and vaginal administration of progesterone.
ISSN:0378-5122
1873-4111
DOI:10.1016/0378-5122(94)00882-8