Emergence of functional circuits in ferret visual cortex visualized by optical imaging

The emergence of functional lateral interactions in ferret visual cortex was monitored using high speed optical imaging of voltage-sensitive dye signals in brain slices. Prior to the time of eye opening, lateral activation was restricted to a narrow columnar region. During the week following eye ope...

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Bibliographic Details
Published in:Neuron (Cambridge, Mass.) Mass.), 1995-07, Vol.15 (1), p.23-34
Main Authors: Nelson, Darin A., Katz, Lawrence C.
Format: Article
Language:English
Subjects:
Age Factors
Animals
Axons - ultrastructure
Coloring Agents
Evoked Potentials, Visual - drug effects
Evoked Potentials, Visual - physiology
Ferrets - physiology
Image Processing, Computer-Assisted
Kynurenic Acid - pharmacology
Membrane Potentials - physiology
Neural Inhibition - physiology
Time Factors
Visual Cortex - cytology
Visual Cortex - physiology
Visual Pathways - cytology
Visual Pathways - physiology
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Summary:The emergence of functional lateral interactions in ferret visual cortex was monitored using high speed optical imaging of voltage-sensitive dye signals in brain slices. Prior to the time of eye opening, lateral activation was restricted to a narrow columnar region. During the week following eye opening, the extent of lateral propagation of activity more than doubled. Selective interruption of specific pathways in the slice, combined with pharmacological and anatomical experiments, determined that this lateral propagation was mediated by horizontal projections made within layer 2 3 . These results indicate that functional horizontal interactions emerge only after axons begin branching and in parallel with, but not prior to, the refinement of orientation selectivity.
ISSN:0896-6273
1097-4199
DOI:10.1016/0896-6273(95)90061-6