Levels of Interferon in the Plasma and Cerebrospinal Fluid of Patients with Acute Japanese Encephalitis

Interferon has been shown to be active against Japanese encephalitis (JE) in murine models, but the role of alpha interferon (IFN- alpha ) in recovery from acute JE in humans is unknown. To test the hypothesis that IFN- alpha is important in the recovery from acute JE, the authors measured the activ...

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Bibliographic Details
Published in:The Journal of infectious diseases 1987-04, Vol.155 (4), p.797-799
Main Authors: Burke, Donald S., Morrill, Lohn C.
Format: Article
Language:English
Subjects:
Acute Disease
Biological and medical sciences
Cerebrospinal fluid
Child
Child, Preschool
Concise Laboratory and Clinical Communications
Encephalitis, Japanese - cerebrospinal fluid
Encephalitis, Japanese - immunology
Female
Health outcomes
Hospital admissions
Human viral diseases
Humans
Infectious diseases
Interferon Type I - analysis
Interferon Type I - blood
Interferon Type I - cerebrospinal fluid
Interferons
Japanese encephalitis
Japanese encephalitis virus
Japanese encephalitis viruses
Leukocytes
Male
Medical sciences
Ungulates
Viral diseases
Viral diseases of the nervous system
Viruses
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Description
Summary:Interferon has been shown to be active against Japanese encephalitis (JE) in murine models, but the role of alpha interferon (IFN- alpha ) in recovery from acute JE in humans is unknown. To test the hypothesis that IFN- alpha is important in the recovery from acute JE, the authors measured the activity levels of IFN- alpha in plasma and CSF specimens from patients who died of acute JE and those who survived.
ISSN:0022-1899
1537-6613
DOI:10.1093/infdis/155.4.797