A Role in B Cell Activation for CD22 and the Protein Tyrosine Phosphatase SHP

CD22 is a membrane immunoglobulin (mlg)-associated protein of B cells. CD22 is tyrosine-phosphorylated when mlg is ligated. Tyrosine-phosphorylated CD22 binds and activates SHP, a protein tyrosine phosphatase known to negatively regulate signaling through mlg. Ligation of CD22 to prevent its coaggre...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1995-07, Vol.269 (5221), p.242-244
Main Authors: Doody, Gina M., Justement, Louis B., Delibrias, Catherine C., Matthews, R. James, Lin, Jiejian, Thomas, Matthew L., Fearon, Douglas T.
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Analysis of the immune response. Humoral and cellular immunity
Animals
Antibodies
Antigens
Antigens, CD - immunology
Antigens, CD - metabolism
Antigens, Differentiation, B-Lymphocyte - immunology
Antigens, Differentiation, B-Lymphocyte - metabolism
B cells
B lymphocytes
B-Lymphocytes - immunology
Biochemistry
Biological and medical sciences
Cell Adhesion Molecules
Cell differentiation
Cells, Cultured
Cellular biology
Cellulose nitrate
Differentiation
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Humans
Immunobiology
Immunoglobulin M - immunology
Individualized Instruction
Intracellular Signaling Peptides and Proteins
Lectins
Ligation
Lymphocyte Activation
Mice
Miscellaneous
Molecular Sequence Data
Phosphatases
Phosphorylation
Protein tyrosine kinase
Protein Tyrosine Phosphatase, Non-Receptor Type 11
Protein Tyrosine Phosphatase, Non-Receptor Type 6
Protein Tyrosine Phosphatases - metabolism
Proteins
Receptors
Recombinant Proteins - metabolism
Regulatory factors and their cellular receptors
Sialic Acid Binding Ig-like Lectin 2
Signal Transduction
T lymphocytes
Tumor Cells, Cultured
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Description
Summary:CD22 is a membrane immunoglobulin (mlg)-associated protein of B cells. CD22 is tyrosine-phosphorylated when mlg is ligated. Tyrosine-phosphorylated CD22 binds and activates SHP, a protein tyrosine phosphatase known to negatively regulate signaling through mlg. Ligation of CD22 to prevent its coaggregation with mlg lowers the threshold at which mlg activates the B cell by a factor of 100. In secondary lymphoid organs, CD22 may be sequestered away from mlg through interactions with counterreceptors on T cells. Thus, CD22 is a molecular switch for SHP that may bias mlg signaling to anatomic sites rich in T cells.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.7618087