Balmoralmycin, a New Angucyclinone, and Two Related Biosynthetic Shunt Products Containing a Novel Ring System

A new angucyclinone, named balmoralmycin (1), was isolated as an inhibitor of protein kinase C-α (PKC-α) from the Streptomyces strain P6417. Chemical screening of extracts of the same strain resulted in the detection of two decaketides with unusual structural features (2 and 3). Both compounds belon...

Full description

Saved in:
Bibliographic Details
Published in:Journal of antibiotics 1995/06/25, Vol.48(6), pp.457-461
Main Authors: BINDSEIL, KAI UWE, HUG, PAUL, PETER, HEINRICH H., PETERSEN, FRANK, ROGGO, BARBARA E.
Format: Article
Language:English
Subjects:
Anthracyclines
Antibiotics, Antineoplastic - chemistry
Antibiotics, Antineoplastic - isolation & purification
Antibiotics, Antineoplastic - pharmacology
Benzophenones - chemistry
Benzophenones - isolation & purification
Biological and medical sciences
Fermentation
Medical sciences
Miscellaneous
Molecular Structure
Naphthacenes - chemistry
Naphthacenes - isolation & purification
Pharmacology. Drug treatments
Protein Kinase C - antagonists & inhibitors
Pyrones - chemistry
Pyrones - isolation & purification
Streptomyces
Structure-Activity Relationship
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A new angucyclinone, named balmoralmycin (1), was isolated as an inhibitor of protein kinase C-α (PKC-α) from the Streptomyces strain P6417. Chemical screening of extracts of the same strain resulted in the detection of two decaketides with unusual structural features (2 and 3). Both compounds belong to a recently described structural class of secondary metabolites which arises from engineered biosynthesis of a recombinant Streptomyces strain. The isolation of compounds of this class from a wild-type strain has never been reported before.
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.48.457