Cancer in Families With Severe Combined Immune Deficiency

Cancer incidence and mortality were analyzed in 1,181 blood relatives and 558 spouse controls in 24 families of severe combined immune deficiency (SCID) patients, to test the hypothesis that heterozygous carriers of a gene for an autosomal recessive form of SCID are predisposed to cancer. Since at l...

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Bibliographic Details
Published in:JNCI : Journal of the National Cancer Institute 1987-03, Vol.78 (3), p.455-458
Main Authors: Morrell, Daphne, Chase, Charles L., Swift, Michael
Format: Article
Language:English
Subjects:
Adenosine Deaminase - deficiency
Adult
Biological and medical sciences
Child, Preschool
Disease Susceptibility
Epidemiology
Female
Genes, Recessive
Heterozygote
Humans
Immunologic Deficiency Syndromes - complications
Immunologic Deficiency Syndromes - genetics
Infant
Male
Medical sciences
Neoplasms - etiology
Neoplasms - genetics
Neoplasms - immunology
Neoplastic Syndromes, Hereditary - immunology
Tumors
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Summary:Cancer incidence and mortality were analyzed in 1,181 blood relatives and 558 spouse controls in 24 families of severe combined immune deficiency (SCID) patients, to test the hypothesis that heterozygous carriers of a gene for an autosomal recessive form of SCID are predisposed to cancer. Since at least 1 patient in each family was female and there were no cases outside the probands' sibships, the pattern of occurrence of SCID within the families was compatible with autosomal recessive inheritance. The observed numbers of cancer cases and deaths did not exceed the expected numbers derived from population-based rates; and there was no cancer excess when incidence rates in blood relatives were compared directly to those in spouse controls, since the rate ratios were 1.2 and 1.0 for males and females, respectively. In addition, cancer rate ratios were not significantly elevated when calculated separately for the 9 families of adenosine deaminase (ADA)-deficient SCID patients and for the 15 families without evidence of ADA deficiency.
ISSN:0027-8874
1460-2105
DOI:10.1093/jnci/78.3.455