Tyrosinase Inhibitors from Bolivian Medicinal Plants

Bioassay-guided fractionation monitored by mushroom tyrosinase (EC 1.14.18.1) activity, afforded six inhibitors from three Bolivian medicinal plants, Buddleia coriacea, Gnaphalium cheiranthifolium, and Scheelea princeps. These inhibitors, which are all known phenolic compounds, inhibited the oxidati...

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 1995-05, Vol.58 (5), p.739-743
Main Authors: Kubo, Isao, Yokokawa, Yoshihiro, Kinst-Hori, Ikuyo
Format: Article
Language:English
Subjects:
Basidiomycota - enzymology
BOLIVIA
BOLIVIE
BUDDLEIA CORIACEA
BUDDLEJA
CHEMICAL COMPOSITION
COMPOSE PHENOLIQUE
COMPOSICION QUIMICA
COMPOSITAE
COMPOSITION CHIMIQUE
COMPUESTOS FENOLICOS
DOPA
DRUG PLANTS
ENZYME INHIBITORS
GNAPHALIUM
GNAPHALIUM CHEIRANTHIFOLIUM
INHIBIDORES DE ENZIMAS
INHIBITEUR D'ENZYME
MOLECULAR CONFORMATION
MOLECULAR STRUCTURE
Monophenol Monooxygenase - antagonists & inhibitors
OXIDACION
OXIDATION
OXYDATION
PALMAE
PHENOLIC COMPOUNDS
PLANTAS MEDICINALES
PLANTE MEDICINALE
Plants, Medicinal - chemistry
SCHEELEA PRINCEPS
TIROSINA
TYROSINE
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Description
Summary:Bioassay-guided fractionation monitored by mushroom tyrosinase (EC 1.14.18.1) activity, afforded six inhibitors from three Bolivian medicinal plants, Buddleia coriacea, Gnaphalium cheiranthifolium, and Scheelea princeps. These inhibitors, which are all known phenolic compounds, inhibited the oxidation of L-3,4-dihydroxyphenylalanine (L-DOPA) mediated by a mushroom tyrosinase.
ISSN:0163-3864
1520-6025
DOI:10.1021/np50119a013