Template-directed oligonucleotide ligation on hydroxylapatite

It has been suggested that the prebiotic synthesis of the precursors of biopolymers could have occurred on a solid surface such as that provided by clay or some other mineral. One such scheme envisages that growing polymers were localized by adsorption to a mineral surface where an activating agent...

Full description

Saved in:
Bibliographic Details
Published in:Nature (London) 1986-06, Vol.321 (6072), p.790-792
Main Authors: Acevedo, O. L., Orgel, L. E.
Format: Article
Language:English
Subjects:
Adsorption
Durapatite - chemistry
Evolution, Chemical
Evolution, Molecular
Guanosine Monophosphate - analogs & derivatives
Guanosine Monophosphate - chemistry
Humanities and Social Sciences
Imidazoles - analysis
Imidazoles - chemistry
letter
Life Sciences (General)
multidisciplinary
Oligonucleotides - chemical synthesis
Oligonucleotides - chemistry
Origin of Life
Poly C - chemistry
Science
Science (multidisciplinary)
Space life sciences
Templates, Genetic
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:It has been suggested that the prebiotic synthesis of the precursors of biopolymers could have occurred on a solid surface such as that provided by clay or some other mineral. One such scheme envisages that growing polymers were localized by adsorption to a mineral surface where an activating agent or activated monomers were supplied continuously or cyclically. Here, it is reported that a sequence of reactions in which initially formed oligo(G)s are reactivated by conversion to phosphorimidazolides in the presence of poly(C) and then allowed to ligate is ideal, in that repeated cycles can be carried out on the surface of hydroxylapatite, whereas in the liquid phase the cycle could be achieved only with considerable difficulty.
ISSN:0028-0836
1476-4687
DOI:10.1038/321790a0