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Template-directed oligonucleotide ligation on hydroxylapatite

It has been suggested that the prebiotic synthesis of the precursors of biopolymers could have occurred on a solid surface such as that provided by clay or some other mineral. One such scheme envisages that growing polymers were localized by adsorption to a mineral surface where an activating agent...

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Published in:	Nature (London) 1986-06, Vol.321 (6072), p.790-792
Main Authors:	Acevedo, O. L., Orgel, L. E.
Format:	Article
Language:	English
Subjects:	Adsorption Durapatite - chemistry Evolution, Chemical Evolution, Molecular Guanosine Monophosphate - analogs & derivatives Guanosine Monophosphate - chemistry Humanities and Social Sciences Imidazoles - analysis Imidazoles - chemistry letter Life Sciences (General) multidisciplinary Oligonucleotides - chemical synthesis Oligonucleotides - chemistry Origin of Life Poly C - chemistry Science Science (multidisciplinary) Space life sciences Templates, Genetic
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description	It has been suggested that the prebiotic synthesis of the precursors of biopolymers could have occurred on a solid surface such as that provided by clay or some other mineral. One such scheme envisages that growing polymers were localized by adsorption to a mineral surface where an activating agent or activated monomers were supplied continuously or cyclically. Here, it is reported that a sequence of reactions in which initially formed oligo(G)s are reactivated by conversion to phosphorimidazolides in the presence of poly(C) and then allowed to ligate is ideal, in that repeated cycles can be carried out on the surface of hydroxylapatite, whereas in the liquid phase the cycle could be achieved only with considerable difficulty.
doi_str_mv	10.1038/321790a0
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Here, it is reported that a sequence of reactions in which initially formed oligo(G)s are reactivated by conversion to phosphorimidazolides in the presence of poly(C) and then allowed to ligate is ideal, in that repeated cycles can be carried out on the surface of hydroxylapatite, whereas in the liquid phase the cycle could be achieved only with considerable difficulty.</description><identifier>ISSN: 0028-0836</identifier><identifier>EISSN: 1476-4687</identifier><identifier>DOI: 10.1038/321790a0</identifier><identifier>PMID: 11540863</identifier><language>eng</language><publisher>Legacy CDMS: Nature Publishing Group UK</publisher><subject>Adsorption ; Durapatite - chemistry ; Evolution, Chemical ; Evolution, Molecular ; Guanosine Monophosphate - analogs & derivatives ; Guanosine Monophosphate - chemistry ; Humanities and Social Sciences ; Imidazoles - analysis ; Imidazoles - chemistry ; letter ; Life Sciences (General) ; multidisciplinary ; Oligonucleotides - chemical synthesis ; Oligonucleotides - chemistry ; Origin of Life ; Poly C - chemistry ; Science ; Science (multidisciplinary) ; Space life sciences ; Templates, Genetic</subject><ispartof>Nature (London), 1986-06, Vol.321 (6072), p.790-792</ispartof><rights>Springer Nature Limited 1986</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c388t-eef251d06fcac16e888a61933166dbbb71ace6f5f90b8ea0b7ce699fc9d82bdf3</citedby><cites>FETCH-LOGICAL-c388t-eef251d06fcac16e888a61933166dbbb71ace6f5f90b8ea0b7ce699fc9d82bdf3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,2727,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11540863$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Acevedo, O. 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subjects	Adsorption Durapatite - chemistry Evolution, Chemical Evolution, Molecular Guanosine Monophosphate - analogs & derivatives Guanosine Monophosphate - chemistry Humanities and Social Sciences Imidazoles - analysis Imidazoles - chemistry letter Life Sciences (General) multidisciplinary Oligonucleotides - chemical synthesis Oligonucleotides - chemistry Origin of Life Poly C - chemistry Science Science (multidisciplinary) Space life sciences Templates, Genetic
title	Template-directed oligonucleotide ligation on hydroxylapatite
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