Equal IgG Antibody Response to Pneumococcal Vaccination in All Stages of Human Immunodeficiency Virus Disease

To evaluate the immunogenicity and safety of a 23-valent pneumococcal vaccine in human immunodeficiency virus (HIV)-seropositive patients, 80 men and 18 women received 1 dose of the vaccine (Pneumo 23; Pasteur Mérieux MSD, Brussels). The total IgG antibody response against all 23 Streptococcus pneum...

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Bibliographic Details
Published in:The Journal of infectious diseases 1995-08, Vol.172 (2), p.551-553
Main Authors: Vandenbruaene, Marc, Colebunders, R., Mascart-Lemone, F., Haerden, Y., Van Hove, D., Peeters, M., Goeman, J., Van Royen, P., Avonts, D.
Format: Article
Language:English
Subjects:
Adult
AIDS
AIDS/HIV
Antibodies
Antibody Formation
Antigens
Bacterial Vaccines - immunology
Biological and medical sciences
CD4 Lymphocyte Count
Concise Communications
Female
HIV
HIV infections
HIV Infections - immunology
HIV Seropositivity - immunology
Humans
Immune response
Immunodeficiencies
Immunodeficiencies. Immunoglobulinopathies
Immunoglobulin G - blood
Immunopathology
Male
Medical sciences
Pneumococcal vaccine
Pneumococcal Vaccines
Polysaccharides
Streptococcus pneumoniae - immunology
Vaccination
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Summary:To evaluate the immunogenicity and safety of a 23-valent pneumococcal vaccine in human immunodeficiency virus (HIV)-seropositive patients, 80 men and 18 women received 1 dose of the vaccine (Pneumo 23; Pasteur Mérieux MSD, Brussels). The total IgG antibody response against all 23 Streptococcus pneumoniae capsular antigens was measured. Antibody levels were expressed in arbitrary units per microliter, referring to a standard curve. Geometric mean titers of the total IgG capsular antibodies on the day of vaccination and 30–45 days later were compared. The ratios of titers after and before vaccination in patients with >500,200–500, and
ISSN:0022-1899
1537-6613
DOI:10.1093/infdis/172.2.551