Aberrant expression of the growth factor Wnt-5A in human malignancy

The Wnt-5A gene codes for a secreted cysteine-rich growth factor that mediates cell to cell signaling via a paracrine mechanism during development and ontogeny. We have recently determine the genomic organization and chromosomal mapping of the human Wnt-5A, and observed distinct patterns of expressi...

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Bibliographic Details
Published in:Cancer research (Chicago, Ill.) Ill.), 1995-08, Vol.55 (16), p.3495-3499
Main Authors: IOZZO, R. V, EICHSTETTER, I, DANIELSON, K. G
Format: Article
Language:English
Subjects:
Biological and medical sciences
Gene Expression Regulation, Neoplastic
Genes
Growth Substances - genetics
Humans
In Vitro Techniques
Medical sciences
Multiple tumors. Solid tumors. Tumors in childhood (general aspects)
Proto-Oncogene Proteins - genetics
RNA, Messenger - genetics
RNA, Neoplasm - genetics
Tissue Distribution
Tumor Cells, Cultured
Tumors
Wnt Proteins
Wnt-5a Protein
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Summary:The Wnt-5A gene codes for a secreted cysteine-rich growth factor that mediates cell to cell signaling via a paracrine mechanism during development and ontogeny. We have recently determine the genomic organization and chromosomal mapping of the human Wnt-5A, and observed distinct patterns of expression in developing human embryos. In this report, we have performed a detailed expression analysis of 100 adult human tissues and tumors and 10 human cell lines. Our data show a widespread expression of Wnt-5A in adult tissues and cells, and aberrant mRNA levels in lungs, breast, and prostate carcinomas and in melanomas. The up-regulation of Wnt-5A in human malignancy was not due to either gene rearrangement or amplification. These findings document an abnormal expression of this growth factor in malignancy and implicate Wnt-5A in the genesis of human cancer.
ISSN:0008-5472
1538-7445