Transient reduction of autoantibodies against oxidized ldl in patients with acute myocardial infarction

• Published in: Free radical biology & medicine 1995-06, Vol.18 (6), p.1087-1091
• Main Authors: Schumacher, Martin, Eber, Bernd, Tatzber, Franz, Kaufmann, Peter, Halwachs, Gabriele, Fruhwald, Friedrich M., Zweiker, Robert, Esterbauer, Hermann, Klein, Werner
• Format: Article
• Language: English
• Subjects: Acute myocardial infarction; Adult; Aged; Aged, 80 and over; Autoantibodies - blood; Creatine Kinase - blood; Female; Free radicals; Humans; Isoenzymes; Kinetics; Lipoproteins, LDL - immunology; Male; Middle Aged; Myocardial Infarction - enzymology; Myocardial Infarction - immunology; Oxidation-Reduction; Oxidized LDL autoantibodies
• ISSN: 0891-5849; 1873-4596
• DOI: 10.1016/0891-5849(94)00216-7

Fifteen consecutive patients (mean age 66 ± 14, range 31–82) with an acute myocardial infarction (MI) suitable for thrombolytic therapy were included in this study. Autoantibodies against oxidized low-density lipoprotein (LDL) were determined by enzyme-linked immunosorbent assay (ELISA). Patients ( n = 10) with marked elevation of the MB isoenzyme of creatinine kinase (CK-MB)-mass had significant decreases of oLDL-Ab during the acute phase, with a minimum after 8 h following the onset of thrombolytic therapy (within-group significance: p < .001; between groups: p = .01). Patients ( n = 5) with CK-MB-mass values less than 70 ng/ml did not show this phenomenon. Furthermore, significant correlations existed between CK-MB-mass and oLDL-Ab after 6 and 8 h ( n = 15; r = .72; p = .003) and the time of the highest CK-MB-mass values (after 12 h) and the time of the maximal decrease of oLDL-Ab (after 8 h) ( r = .74; p = .003). Our observations provide further evidence for the release of free radicals and for increased lipid peroxidation during reperfusion after prolonged ischemia. The decrease of oLDL-Ab appears to be a marker for the severity of MI.