The effect of low amniotic pressure without oligohydramnios on fetal lung development in a rabbit model

OBJECTIVE: Our purpose was to examine fetal lung development in reduced intraamniotic pressure without amniotic fluid loss. STUDY DESIGN: A circular portion of uterine wall measuring 1 cm in diameter was excised while the chorionic and amniotic membranes were left intact at the twenty-third day of g...

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Bibliographic Details
Published in:American journal of obstetrics and gynecology 1995-07, Vol.173 (1), p.36-41
Main Authors: Kizilcan, Faith, Tanyel, F.Cahirt, Çakar, Nur, Büyükpamukçu, Nebil, Hiçsönmez, Akgün
Format: Article
Language:English
Subjects:
Amnion
Amniotic Fluid - physiology
Animals
Biological and medical sciences
Diseases of mother, fetus and pregnancy
Female
Fetal Organ Maturity - physiology
Fetus
Gynecology. Andrology. Obstetrics
Hernia - physiopathology
Lung - embryology
lung hypoplasia
Medical sciences
oligohydramnios
Pregnancy
Pregnancy. Fetus. Placenta
Pressure
Rabbits
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Summary:OBJECTIVE: Our purpose was to examine fetal lung development in reduced intraamniotic pressure without amniotic fluid loss. STUDY DESIGN: A circular portion of uterine wall measuring 1 cm in diameter was excised while the chorionic and amniotic membranes were left intact at the twenty-third day of gestation in Nez Zealand White rabbits. The chorionic and amniotic membranes herniated spontaneously through the defect. RESULTS: Amniotic pressure was significantly reduced after herniation. Lung weight/body weight ratios at term who significantly reduced in experimental fetuses compared with controls. Residual amniotic fluid volumes at term did not differ. Histopathologic examination of lung specimens showed that fetal lungs had not matured in the experimental group as fully as in the control group. CONCLUSION: This experimental study demonstrated that low amniotic pressure impaired fetal lung development, even without oligohydramnios.
ISSN:0002-9378
1097-6868
DOI:10.1016/0002-9378(95)90166-3