hBD-1: a novel β-defensin from human plasma

We report the isolation and characterization of a novel peptide with significant sequence homology to β-defensins from human blood filtrate. The human β-defensin-1 (hBD-1) is a short basic peptide of 36 amino acid residues. It contains six cysteines forming three intramolecular disulfide bonds. The...

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Bibliographic Details
Published in:FEBS letters 1995-07, Vol.368 (2), p.331-335
Main Authors: Bensch, Klaus W., Raida, Manfred, Mägert, Hans-Jürgen, Schulz-Knappe, Peter, Forssmann, Wolf-Georg
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Amino Acids - analysis
Animals
Antimicrobial peptide
Base Sequence
beta-Defensins
Blood
Blood Proteins - chemistry
Blood Proteins - genetics
Blood Proteins - isolation & purification
Cattle
cDNA
Chickens
Cloning, Molecular
Defensins
DNA, Complementary - analysis
DNA, Complementary - genetics
Female
Hemofiltrate
Hemofiltration
Humans
Kidney - chemistry
Molecular Sequence Data
Molecular Weight
Sequence Analysis
Sequence Analysis, DNA
Sequence Homology, Amino Acid
Vagina - chemistry
β-Defensin
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Summary:We report the isolation and characterization of a novel peptide with significant sequence homology to β-defensins from human blood filtrate. The human β-defensin-1 (hBD-1) is a short basic peptide of 36 amino acid residues. It contains six cysteines forming three intramolecular disulfide bonds. The molecular mass of hBD-1 is 3928.6 Da. Cloning of the specific cDNA confirmed the amino acid sequence of the native peptide. hBD-1 shares the nine conserved amino acids characteristic for β-defensins from respiratory epithelial cells and neutrophils of cattle and chicken leukocytes. hBD-1 is present in nanomolar concentration in human plasma.
ISSN:0014-5793
1873-3468
DOI:10.1016/0014-5793(95)00687-5