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Synthesis and turnover rates of four rat liver mitochondrial RNA species
The synthesis and turnover rates of the two 12 S and 16 S mt rRNAs and of the mt mRNAs for subunits I and III of cytochrome oxidase have been determined by measuring the kinetics of incorporation of [ 3H]uridine in the mtRNA of rat hepatocytes. All the RNA species examined have approximately the sam...
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Published in: | FEBS letters 1987-03, Vol.213 (1), p.144-148 |
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Main Authors: | , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | The synthesis and turnover rates of the two 12 S and 16 S mt rRNAs and of the mt mRNAs for subunits I and III of cytochrome oxidase have been determined by measuring the kinetics of incorporation of [
3H]uridine in the mtRNA of rat hepatocytes. All the RNA species examined have approximately the same turnover (
t
1
2
~ 100 min) and therefore the rate of synthesis, which is about 10-times higher for the rRNAs, seems to be the factor responsible for the different mt rRNA and mRNA steady-state levels. |
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ISSN: | 0014-5793 1873-3468 |
DOI: | 10.1016/0014-5793(87)81480-1 |