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Synthesis and turnover rates of four rat liver mitochondrial RNA species

The synthesis and turnover rates of the two 12 S and 16 S mt rRNAs and of the mt mRNAs for subunits I and III of cytochrome oxidase have been determined by measuring the kinetics of incorporation of [ 3H]uridine in the mtRNA of rat hepatocytes. All the RNA species examined have approximately the sam...

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Bibliographic Details
Published in:FEBS letters 1987-03, Vol.213 (1), p.144-148
Main Authors: Cantatore, P., Flagella, Z., Fracasso, F., Lezza, A.M.S., Gadaleta, M.N., de Montalvo, A.
Format: Article
Language:English
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Summary:The synthesis and turnover rates of the two 12 S and 16 S mt rRNAs and of the mt mRNAs for subunits I and III of cytochrome oxidase have been determined by measuring the kinetics of incorporation of [ 3H]uridine in the mtRNA of rat hepatocytes. All the RNA species examined have approximately the same turnover ( t 1 2 ~ 100 min) and therefore the rate of synthesis, which is about 10-times higher for the rRNAs, seems to be the factor responsible for the different mt rRNA and mRNA steady-state levels.
ISSN:0014-5793
1873-3468
DOI:10.1016/0014-5793(87)81480-1